-
作者:Daniels, Ronald J.
作者单位:Norwegian Meteorological Institute
-
作者:Zheng, Xin; Valov, Ilia
作者单位:Helmholtz Association; Julich Research Centre; Bulgarian Academy of Sciences
-
作者:Maeso-Diaz, Raquel; Diehl, Anna Mae
作者单位:Duke University
-
作者:Wu, Yun-He; Zhang, Dongru; Shen, Wenjing; Zhang, Tianyi; Kilunda, Felista Kasyoka; Xu, Wei
作者单位:Nanjing Normal University; Liupanshui Normal University; Tel Aviv University
-
作者:Bakkeren, Erik
作者单位:University of Calgary
-
作者:Beketova, Zoe
-
作者:Stone, Richard
作者单位:Norwegian Meteorological Institute
-
作者:Kean, Sam
-
作者:Wellerstein, Alex; Montgomery, Beronda L.; O'Mara, Margaret; Campos, Luis A.; Obasogie, Osagie K.; Conway, Erik M.
作者单位:Stevens Institute of Technology; Institut d'Etudes Politiques Paris (Sciences Po); Grinnell College; University of Washington; University of Washington Seattle; Rice University; University of California System; University of California Berkeley; Purdue University System; Purdue University
-
作者:Pearce, James D.; Simmonds, Sara E.; Mahmoudabadi, Gita; Krishnan, Lakshmi; Palla, Giovanni; Istrate, Ana-Maria; Tarashansky, Alexander; Nelson, Benjamin; Valenzuela, Omar; Li, Donghui; Quake, Stephen R.; Karaletsos, Theofanis
作者单位:Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要:Single-cell transcriptomics is revolutionizing our understanding of cellular diversity, yet comparing transcriptional programs across the tree of life remains challenging. We developed TranscriptFormer, a family of generative foundation models trained on up to 112 million cells spanning 1.53 billion years of evolution across 12 species. We demonstrate state-of-the-art performance on cell type classification, even for species separated by over 685 million years of evolution, and zero-shot disea...