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作者:Arora, Ashish; Belenzon, Sharon
作者单位:Duke University; National Bureau of Economic Research
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作者:Schmitt, Christin; Krishnia, Sachin; Zeer, Mahmoud; Galindez-Ruales, Edgar; Loyal, Mehak; Kohler, Jonas; Micus, Luca; Kikkawa, Takashi; Arisawa, Hiroki; Denneulin, Thibaud; Kovacs, Andras; Xu, Renyou; Tran, Duc; Kronast, Florian; Go, Dongwook; Pourovskii, Leonid V.; Dunin-Borkowski, Rafal E.; Kuschel, Timo; Lezaic, Marjana; Sinova, Jairo; Saitoh, Eiji; Jakob, Gerhard; Gomonay, Olena; Mokrousov, Yuriy; Klaui, Mathias
作者单位:Johannes Gutenberg University of Mainz; Helmholtz Association; Julich Research Centre; University of Tokyo; Japan Atomic Energy Agency; RIKEN; Helmholtz Association; Julich Research Centre; Beihang University; Helmholtz Association; Helmholtz-Zentrum fuer Materialien und Energie GmbH (HZB); Korea University; Institut Polytechnique de Paris; Centre National de la Recherche Scientifique (CNRS); Ecole Polytechnique; Universite PSL; College de France; University of Bielefeld; Texas A&M University System; Texas A&M University College Station; Tohoku University; University of Tokyo; Norwegian University of Science & Technology (NTNU)
摘要:Recent predictions of orders of magnitude larger orbital current effects compared with spin currents have attracted considerable interest. However, orbital currents must first be converted into spin currents to interact with the static magnetization dominated by spin angular momentum in conventional magnets. By using a magnet dominated by orbital angular momentum (OAM), we demonstrate a 70-fold enhancement in orbital Hall magnetoresistance in cobalt II oxide/copper (CoO/Cu*), compared with spi...
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作者:Zhang, Ying; Sun, Yuzhuo; Xu, Guangkui; Wu, Yue; Shi, Zhijun; Chang, Zhuo; Liu, Junjun; Pang, Kaidan; Liu, Siyu; Wang, Han; Rong, Weixin; Shao, Zehua; Liu, Xingqian; He, Yu; Yan, Yang; Zhou, Bin; Yuan, Zuyi; Zhang, Xu-Feng; Offermanns, Stefan; Wang, Shengpeng
作者单位:Xi'an Jiaotong University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Max Planck Society; Goethe University Frankfurt
摘要:The liver exhibits a marked regenerative capacity organized through distinct zones, yet how tissue mechanics coordinate zonated proliferation remains elusive. We reveal that mechanical cues critically contribute to mouse liver regeneration in a highly region-specific manner through sensing by a subpopulation of mid-lobular hepatocytes, which are characterized by dipeptidyl peptidase-4 (DPP4) expression and represent the key proliferative pool of hepatocytes. PIEZO1 is a primary mechanosensor e...
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作者:Cross, Michael; Kotschi, Stefan; Wu, Warren; Luciano-Mateo, Fedra; Kwon, Young-Yon; Dantas, Ezequiel; Niazi, Taha; Chen, Shijia; Rashidfarrokhi, Ali; Pillai, Ray; Sanford, Jack; Kim, Jeshua; Hsiang, Juliya; Gamallo-Lana, Begona; Mar, Adam C.; Hao, Yuan; Rajalingam, Sahith; Huang, Annie; Shan, Jackie; Issa, Habon A.; Gomez, Maria; Wang, Alice R.; Zhao, Xiang; Janowitz, Tobias; White, Eileen; Liu, Yin; Wong, Kwok-Kin; Segal, Leopoldo N.; Hui, Sheng; Goncalves, Marcus D.; Froemke, Robert C.; Papagiannakopoulos, Thales
作者单位:New York University; Harvard University; Harvard T.H. Chan School of Public Health; New York University; New York University; New York University; New York University; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers Cancer Institute of New Jersey; Rutgers University System; Rutgers University New Brunswick; Ludwig Institute for Cancer Research; Princeton University; Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Northwell Health; Howard Hughes Medical Institute
摘要:Sickness behaviors are common in cancer-associated cachexia and affect up to half of lung cancer patients. We demonstrate that among the most common cancer mutations, loss of liver kinase B1 (Lkb1) promotes the development of cachexia in preclinical models of lung cancer. In an effort to improve caloric intake with an obesogenic high-fat diet, we paradoxically observed worsened cachexia-associated sickness. We found that local production of prostaglandin E2 (PGE2), rather than circulating fact...
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作者:Eng, Sothy
作者单位:University of Hawaii System; University of Hawaii Manoa
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作者:Gultekin, Yetis; Vander Heiden, Matthew G.
作者单位:University of Toronto
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作者:Cai, Lei; Tao, Yaoyu; Xie, Chenchen; Yan, Longhao; Li, Shiqian; Shen, Ruihong; Pan, Zelun; Wang, Xile; Wang, Bowen; Shi, Daijing; Zhu, Yihang; Zhang, Teng; Zhu, Yixin; Li, Xi; Song, Zhitang; Huang, Ru; Yang, Yuchao
作者单位:Peking University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Peking University; Peking University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Chinese Institute for Brain Research, Beijing
摘要:High-fidelity geometry for physical-world modeling demands real-time, dense, and differentiable deformation fields on manifolds. Neural dynamical systems (NDSs) using adaptive stepsize integration with embedded neural networks excel at these tasks but still suffer latency on the order of hundreds of milliseconds. In this work, we report a sub-10-millisecond NDS hardware leveraging the precisely controlled conductance drift of phase-change memristors and their multilevel compute-in-memory capab...
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作者:Gernon, Thomas M.; Hincks, Thea K.; Goodwin, Philip; Paxman, Guy J. G.; Brune, Sascha; Rohling, Eelco J.; Keir, Derek; Braun, Jean
作者单位:NERC National Oceanography Centre; University of Southampton; Helmholtz Association; GFZ Helmholtz Centre for Geosciences; Durham University; University of Potsdam; Utrecht University; University of Florence
摘要:Why Antarctica became glaciated similar to 34 million years ago (Ma) remains debated, as relatively warm climates and sea temperatures appear inconsistent with ice sheet formation. Although a critical decline in CO2 is considered primarily responsible, evidence suggests that other factors were important, too. We investigated whether regional topographic uplift, rooted in Jurassic continental breakup and mantle-surface feedbacks, enabled nucleation of the East Antarctic Ice Sheet (EAIS). By int...
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作者:Gross, Daniel P.; Sampat, Bhaven N.
作者单位:Duke University; National Bureau of Economic Research; Johns Hopkins University
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作者:Kupferschmidt, Kai