6806期

最新文章

• Making time AI翻译
  作者：Levine, Joel D.
  作者单位：University of Toronto
• NIH again faces year-end grantmaking scramble AI翻译
  作者：Kaiser, Jocelyn
• NIH security rules for genomic data sets are slowing research AI翻译
  作者：Michelman, Georgia
• In Science Journals AI翻译
  作者：Aldenderfer, Mark; Stajic, Jelena; Szuromi, Phil; Ferrarelli, Leslie K.; Horgan, Briony; Sonawala, Unnati; Seale, Madeleine; Ray, L. Bryan; Nusinovich, Yevgeniya; Smith, Jesse; Funk, Michael A.; Jiang, Di; Ross, Sarah H.; Kelly, Priscilla N.; Suleymanov, Yury; Lopez, Bianca; Bere, Leoma; Malo, Courtney
• A Hormone Cell Atlas maps the human endocrine system at cellular resolution AI翻译
  作者：Fei, Lijiang; Huang-Doran, Isabel; Lawler, Katherine; Yu, Yizhou; Pett, Jan Patrick; Mendez-Acevedo, Kevin M.; Shah, Dinesh; Margalef-Rieres, Jaume; Pohlman, Joseph S.; Cakir, Batuhan; Moy, Madelyn R.; Legg, Robert G.; Xu, Chuan; To, Ken; Pham, Duy; Predeus, Alexander V.; Hanssen, Ruth; Cacciottolo, Tessa M.; Kapuge, Rakesh K.; Polanski, Krzysztof; Oliver, Amanda J.; Teichmann, Sarah A.; Farooqi, I. Sadaf
  作者单位：University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; Wellcome Trust Sanger Institute; University of Cambridge; University of Cologne; Imperial College London; QIMR Berghofer Medical Research Institute; University of Cambridge
  摘要：Hormones act across tissues and organs to coordinate physiological functions. Drawing inspiration from the Human Cell Atlas, we analyzed the expression of 379 hormone and receptor genes in a transcriptomic dataset comprising 14 million single cells and nuclei across 47 human tissues. Using hormone2cell, we mapped putative hormone-producing and hormone-receiving cell types, defining tissue-specific and cross-tissue endocrine signatures. We predicted nonclassical sites of hormone expression, inc...
• Height does not impair the hydraulic system of the tallest tropical Dipterocarp trees AI翻译
  作者：Bittencourt, Paulo; Scheire, Arne; Jotan, Palasiah; Lourenco, Jehova; Banin, Lindsay F.; bin Suis, Mohd Aminur Faiz; Burslem, David F. R. P.; Christoffersen, Bradley; Coomes, David; Groenendijk, Peter; Jansen, Steven; Jucker, Tommaso; Matula, Radim; Mencuccini, Maurizio; Oliveira, Rafael; Plichta, Roman; Nilus, Reuben; Robert, Rolando; Svatek, Martin; Rowland, Lucy
  作者单位：Cardiff University; University of Exeter; Czech University of Life Sciences Prague; Royal Botanic Gardens, Kew; UK Centre for Ecology & Hydrology (UKCEH); Pusat Penyelidikan Hutan; Universiti Malaysia Sabah; University of Aberdeen; University of Texas System; University of Texas Rio Grande Valley; University of Cambridge; Universidade de Sao Paulo; Universidade Estadual de Campinas; Ulm University; University of Bristol; ICREA; Mendel University in Brno
  摘要：Half of the aboveground biomass in forests is stored in a disproportionately small number of very tall trees. These giants are predicted to be more vulnerable to drought-induced damage because height impairs their hydraulic system. We evaluated whether the hydraulic system of world's tallest tropical tree species-Southeast Asian dipterocarps-are negatively affected by their height. The more negative xylem pressures caused by tree height were fully compensated for through adjustment of vessel a...
• The invisible hand AI翻译
  作者：Zhu, Yibin
  作者单位：Tsinghua University
• Fruit flies actively restart their circadian clock by proactively shaping their environment AI翻译
  作者：Coculla, Angelica; Garcia Rodriguez, Luis; Ogueta, Maite; Stanewsky, Ralf
  作者单位：University of Munster
  摘要：Circadian clocks provide adaptive advantages, enabling organisms to adjust their physiology and behavior to daily environmental changes on Earth. Here, we show that fruit flies prefer a temporally organized life. Because of light-induced degradation of the core circadian clock protein Timeless, constant illumination stops the circadian clock and leads to arrhythmic locomotor activity. When given the choice to move between dark and illuminated areas in a constant light environment, flies were a...
• In Other Journals AI翻译
  作者：Hurtley, Stella M.; Sirois, Cheri; Jiang, Di; McCartney, Melissa; Maroso, Mattia; Osborne, Ian S.; Huang, Jack
• Membrane protein solubilization and structure determination using de novo-designed proteins AI翻译
  作者：Mihaljevic, Ljubica; Kim, David E.; Bandawane, Pooja D.; Eisenach, Helen E.; Borst, Andrew J.; Courbet, Alexis; Weidle, Connor; Carr, Kenneth D.; Bettin, Everton; Liu, Qiushi; Trejos, Aldo T.; Majumder, Sagardip; Kokane, Surabhi; Stevens, Alexander; Muratspahic, Edin; Schlichthaerle, Thomas; Exposit, Marc; Li, Xinting; Lamb, Mila; Azcarraga Murray, Analisa Nicole; Ravichandran, Rashmi; Williams, Elizabeth C.; Hu, Shuyuan; Stuart, Lynda; Grillova, Linda; Thomson, Nicholas R.; Landreh, Michael; Chang, Pengxiang; Giacani, Lorenzo; Caimano, Melissa J.; Hawley, Kelly L.; King, Neil P.; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; Howard Hughes Medical Institute; University of Washington Seattle; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Babraham Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Uppsala University; Wellcome Trust Sanger Institute; University of London; London School of Hygiene & Tropical Medicine; Karolinska Institutet
  摘要：Developing therapies and vaccines against integral membrane proteins is hindered by their extensive hydrophobic surfaces, which complicate production and structural analysis. Here, we describe a general deep learning-based design approach for solubilizing native membrane proteins while preserving their sequence, fold, active-site, and ligand-binding properties. Genetically encoded de novo protein WRAPs [water-soluble RFdiffused amphipathic proteins] surround the lipid-interacting hydrophobic s...