6810期

最新文章

• The perils of fluency AI翻译
  作者：Lee, Seungyeon
  作者单位：University of Central Arkansas
• Privacy-preserving tools banned in census AI翻译
  作者：Mervis, Jeffrey
• n-Type polymer layers enable efficient, scalable, and thermally stable perovskite solar modules AI翻译
  作者：Gao, Danpeng; Gong, Jie; Yang, Lei; Wang, Ning; Chang, Bohong; Qian, Liangchen; Vanin, Francesco; Zhang, Chunlei; Yu, Zexin; Li, Shuai; Gong, Jianqiu; Zhu, Zonglong
  作者单位：City University of Hong Kong; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong; City University of Hong Kong
  摘要：Fullerene-based electron transport layers (ETLs) used in inverted (p-i-n) perovskite solar cells face issues regarding cost, scalability, and instability, whereas highly stable inorganic oxides feature unfavorable energy alignment and enhance hysteresis, which reduce power conversion efficiency (PCE). We report a nonfullerene conjugated polymer, 2PB-T, that incorporates coplanar and electron-withdrawing perylene bisimide (PBI) units into its backbone. The PBI polymeric backbone and side-chain ...
• Golden Age report is a missed opportunity, critics say AI翻译
  作者：Mervis, Jeffrey
• The genomic identity of early smallpox in South America AI翻译
  作者：Romero Gonzalez, Bruno; Reyes-Madrid, Margarita; Arriaza, Bernardo; Cassidy, Lara M.; Moraga, Mauricio; Castro, Constanza de la Fuente; Nakagome, Shigeki
  作者单位：Trinity College Dublin; Universidad de Tarapaca; Trinity College Dublin; Universidad de Chile; Kanazawa University
  摘要：Smallpox was a major driver of population collapse in the Americas after European contact, yet the genetic identity of the causal strains remains unknown. Here, we report the first ancient smallpox genomes in the Americas, dating to approximately 1492-1631 common era (CE), recovered from two Inca-Colonial individuals in northern Chile. These genomes form a now-extinct lineage that diverged around 1296 CE, after the splitting of early medieval European strains but before the emergence of modern...
• Beyond the scales: Marine archaeogenomics for the conservation and restoration of fisheries AI翻译
  作者：Atmore, Lane M.; Star, Bastiaan
  作者单位：University of British Columbia; University of Oslo
  摘要：Protection and restoration of marine environments are essential for food security and climate change mitigation. Yet historical and archaeological research have shown that conservation and management often rely on arbitrary ecological baselines in ecosystems already shaped by long-term human impacts. Archaeogenomics, the combination of ancient DNA (aDNA) and whole-genome sequencing, provides invaluable insights into these impacts. Recent improvements in laboratory and computational techniques ...
• Catalytic Appel fluorination of alcohols with potassium fluoride AI翻译
  作者：Mondal, Anirban; Struijs, Job J. C.; Doyle, Caleb J. N.; Chen, Zijun; Wang, Zian; Tangamornchaipattana, Worawit; Allais, Christophe; Richardson, Paul F.; Piper, Jared; Paton, Robert S.; Aldridge, Simon; Gouverneur, Veronique
  作者单位：University of Oxford; Colorado State University System; Colorado State University Fort Collins
  摘要：Appel halogenation reactions are widely used to convert alcohols to alkyl halides but are not suitable to prepare alkyl fluorides because fluoride is sequestered as a difluorophosphorane. In this work, we introduce bench-stable neopentoxyphosphonium salts to solve this enduring challenge. With these reagents, various alcohols undergo fluorination with potassium fluoride under hydrogen bonding phase-transfer catalysis, a manifold offering a pathway to enantioselective fluorination of alcohols. ...
• Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization AI翻译
  作者：Sun, Yunfan; Zhong, Yu; Liu, Shang; Zhang, Zefan; Wang, Chunqing; Liu, Yang; Chen, Junbing; Guo, Wei; Gu, Xiaoying; Rao, Keqiang; Wang, Zifei; Cao, Muzi; Wang, Yue; Huang, Waidong; Zou, Xuanxuan; Chen, Xi; Qiu, Shuangjian; Shi, Yinhong; Sun, Huichuan; Huang, Xiaohu; Wang, Yuhang; Wang, Jiyan; Wu, Zhifang; Tian, Ru; Zhang, Yuanhang; Gu, Jie; Jiang, Miaomiao; Bai, Yinqi; Li, Guibo; Xie, Min; Xi, Feng; Peng, Lihua; Liu, Shiping; Yang, Shuang; Zhang, Yu; Esteban, Miguel A.; Jin, Xin; Chen, Ao; Wang, Jian; Cang, Yong; Peng, David H.; Xu, Xun; Zhou, Jian; Wu, Liang; Fan, Jia
  作者单位：Fudan University; Fudan University; Beijing Genomics Institute (BGI); Chongqing Medical University; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Fudan University; Shanxi Medical University; Shanxi Medical University; Shanxi Medical University; Fudan University; Beijing Genomics Institute (BGI); Fudan University; Fudan University; University of Tabuk; Jinfeng Laboratory
  摘要：The mechanisms underlying the interactions between disseminated tumor cells (DTCs) and their tissue microenvironment during metastatic colonization are currently poorly understood. We integrated multimodal single-cell and spatial profiling from liver cancer mouse models and human metastases to track the spatiotemporal dynamics of DTCs and their microenvironments from single-cell seeding to overt lung metastasis. We identified a residual population of quiescent Phgdhhigh DTCs that survived init...
• The molecular architecture of mammalian vitreous body collagen fibrils AI翻译
  作者：Lou, Xinyao; Cong, Ye; Xu, Yuqian; Liu, Yazhao; Li, Ying; Yan, Chuangye
  作者单位：Tsinghua University; Tsinghua University
  摘要：Collagen, a fundamental constituent of the extracellular matrix, has long remained elusive to high-resolution structural characterization. Using a tailored system and optimized cryo-electron microscopy processing for long-period filaments, we determined the structure of native collagen fibrils from the porcine vitreous body, with local resolutions extending from 2.6 to 7 angstroms. Each 67-nanometer periodic unit contains type II, V/XI, and IX collagen triple helices together with opticin, at ...
• Ancient DNA shows how smallpox got to the Americas AI翻译
  作者：Wade, Lizzie