作者：Na, Jeeyoon; Brunet, Anne
作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University
作者：Cotton, Christopher
作者单位：Queens University - Canada; Queens University - Canada; Queens University - Canada
作者：Kaiser, Jocelyn; Reardon, Sara
作者：McGuire, Jenny L.; Williams, Claire M.
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Texas A&M University System; Texas A&M University College Station
作者：de los Rios Barreda, Jose; Ferreiro, Maria E.; Jansz, Natasha; Bell, Charles C.; Botto, Juan M.; Nguyen, Trung V.; Pradhan, Barun; Chen, Minchun; Colomer-Boronat, Ana; Da Costa Guevara, Darwin J.; Flasch, Diane A.; Gericke, Sabrina; Wilson, Thomas E.; Ewing, Adam D.; Heras, Sara R.; Sanchez-Luque, Francisco J.; Lister, Ryan; Moran, John V.; Faulkner, Geoffrey J.
作者单位：University of Queensland; Mater Research; University of Queensland; Harry Perkins Institute of Medical Research; University of Granada; Pfizer; Pfizer Spain; University of Granada; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN); University of Michigan System; University of Michigan
摘要：X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are hypothesized to facilitate XCI. Here, we used long-read DNA sequencing to conduct a haplotype-aware analysis of engineered L1 integration preferences in the PA-1 human embryonic carcinoma cell line. Crucially, clonal XCI in PA-1 cells enabled derivation of active (Xa) and inactive (Xi) X-chromosom...
作者：Krammer, Sorin M. S.
作者单位：University of Southampton
摘要：Embracing uncertainty, not banishing it, is what makes science powerful
作者：Leckie, R. Mark
作者单位：University of Massachusetts System; University of Massachusetts Amherst
