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作者：Reich, Brian J.; Shaby, Benjamin A.
作者单位：North Carolina State University; University of California System; University of California Berkeley
摘要：Extreme environmental phenomena such as major precipitation events manifestly exhibit spatial dependence. Max-stable processes are a class of asymptotically-justified models that are capable of representing spatial dependence among extreme values. While these models satisfy modeling requirements, they are limited in their utility because their corresponding joint likelihoods are unknown for more than a trivial number of spatial locations, preventing, in particular, Bayesian analyses. In this p...
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作者：Chiquet, Julien; Grandvalet, Yves; Charbonnier, Camille
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Mathematical Sciences (INSMI); Universite Paris Saclay; Universite de Technologie de Compiegne
摘要：We consider the problems of estimation and selection of parameters endowed with a known group structure, when the groups are assumed to be sign-coherent, that is, gathering either nonnegative, nonpositive or null parameters. To tackle this problem, we propose the cooperative-Lasso penalty. We derive the optimality conditions defining the cooperative-Lasso estimate for generalized linear models, and propose an efficient active set algorithm suited to high-dimensional problems. We study the asym...
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作者：Porter, Michael D.; White, Gentry
作者单位：University of Queensland
摘要：A predictive model of terrorist activity is developed by examining the daily number of terrorist attacks in Indonesia from 1994 through 2007. The dynamic model employs a shot noise process to explain the self-exciting nature of the terrorist activities. This estimates the probability of future attacks as a function of the times since the past attacks. In addition, the excess of nonattack days coupled with the presence of multiple coordinated attacks on the same day compelled the use of hurdle ...
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作者：Wei, Peng; Pan, Wei
作者单位：University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; University of Minnesota System; University of Minnesota Twin Cities
摘要：We consider integrative modeling of multiple gene networks and diverse genomic data, including protein-DNA binding, gene expression and DNA sequence data, to accurately identify the regulatory target genes of a transcription factor (TF). Rather than treating all the genes equally and independently a priori in existing joint modeling approaches, we incorporate the biological prior knowledge that neighboring genes on a gene network tend to be (or not to be) regulated together by a TF. A key cont...
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作者：Kim, Seyoung; Xing, Eric P.
作者单位：Carnegie Mellon University
摘要：We consider the problem of estimating a sparse multi-response regression function, with an application to expression quantitative trait locus (eQTL) mapping, where the goal is to discover genetic variations that influence gene-expression levels. In particular, we investigate a shrinkage technique capable of capturing a given hierarchical structure over the responses, such as a hierarchical clustering tree with leaf nodes for responses and internal nodes for clusters of related responses at mul...
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作者：Li, Shaoyu; Cui, Yuehua
作者单位：Michigan State University; St Jude Children's Research Hospital
摘要：Much of the natural variation for a complex trait can be explained by variation in DNA sequence levels. As part of sequence variation, gene-gene interaction has been ubiquitously observed in nature, where its role in shaping the development of an organism has been broadly recognized. The identification of interactions between genetic factors has been progressively pursued via statistical or machine learning approaches. A large body of currently adopted methods, either parametrically or nonpara...
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作者：Baggaley, Andrew W.; Boys, Richard J.; Golightly, Andrew; Sarson, Graeme R.; Shukurov, Anvar
作者单位：Newcastle University - UK
摘要：We consider parameter estimation for the spread of the Neolithic incipient farming across Europe using radiocarbon dates. We model the arrival time of farming at radiocarbon-dated, early Neolithic sites by a numerical solution to an advancing wavefront. We allow for (technical) uncertainty in the radiocarbon data, lack-of-fit of the deterministic model and use a Gaussian process to smooth spatial deviations from the model. Inference for the parameters in the wavefront model is complicated by t...
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作者：Liu, Chong; Ray, Surajit; Hooker, Giles; Friedl, Mark
作者单位：Boston University; Cornell University; Cornell University; Boston University
摘要：We present a new approach to factor rotation for functional data. This is achieved by rotating the functional principal components toward a predefined space of periodic functions designed to decompose the total variation into components that are nearly-periodic and nearly-aperiodic with a predefined period. We show that the factor rotation can be obtained by calculation of canonical correlations between appropriate spaces which make the methodology computationally efficient. Moreover, we demon...
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作者：Liu, Hai; Tu, Wanzhu
作者单位：Indiana University System; Indiana University Bloomington
摘要：This research examines the simultaneous influences of height and weight on longitudinally measured systolic and diastolic blood pressure in children. Previous studies have shown that both height and weight are positively associated with blood pressure. In children, however, the concurrent increases of height and weight have made it all but impossible to discern the effect of height from that of weight. To better understand these influences, we propose to examine the joint effect of height and ...
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作者：Wang, Yong; Ziedins, Ilze; Holmes, Mark; Challands, Neil
作者单位：University of Auckland
摘要：A new family of tree models is proposed, which we call differential trees. A differential tree model is constructed from multiple data sets and aims to detect distributional differences between them. The new methodology differs from the existing difference and change detection techniques in its nonparametric nature, model construction from multiple data sets, and applicability to high-dimensional data. Through a detailed study of an arson case in New Zealand, where an individual is known to ha...
