2024

最新文章

• Transcription-induced active forces suppress chromatin motion AI翻译
  作者：Shin, Sucheol; Shi, Guang; Cho, Hyun Woo; Thirumalai, D.
  作者单位：University of Texas System; University of Texas Austin; University of Illinois System; University of Illinois Urbana-Champaign; Seoul National University of Science & Technology; Seoul National University of Science & Technology; University of Texas System; University of Texas Austin
  摘要：The organization of interphase chromosomes in a number of species is starting to emerge thanks to advances in a variety of experimental techniques. However, much less is known about the dynamics, especially in the functional states of chromatin. Some experiments have shown that the motility of individual loci in human interphase chromosome decreases during transcription and increases upon inhibiting transcription. This is a counterintuitive finding because it is thought that the active mechani...
• In situ formed depot of elastin- like polypeptide- hirudin fusion protein for long- acting antithrombotic therapy AI翻译
  作者：Tian, Xue; Feng, Mingxing; Wei, Xinwei; Cheng, Cheng; He, Kaixin; Jiang, Tianyue; He, Bingfang; Gu, Zhen
  作者单位：Nanjing Tech University; Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory
  摘要：Thrombosis, induced by abnormal coagulation or fibrinolytic systems, is the most common pathology associated with many life- threatening cardio- cerebrovascular diseases. However, first - line anticoagulant drugs suffer from rapid drug elimination and risk of hemorrhagic complications. Here, we developed an in situ formed depot of elastin-like polypeptide (ELP)- hirudin fusion protein with a prodrug-like feature for long - term antithrombotic therapy. Highly secretory expression of the fusion ...
• Variable carbon isotope fractionation of photosynthetic communities over depth in an open- ocean euphotic zone AI翻译
  作者：Henderson, Lillian C.; Wittmers, Fabian; Carlson, Craig A.; Worden, Alexandra Z.; Close, Hilary G.
  作者单位：University of Miami; Marine Biological Laboratory - Woods Hole; University of Kiel; University of California System; University of California Santa Barbara
  摘要：Marine particulate organic carbon (POC) contributes to carbon export, food webs, and sediments, but uncertainties remain in its origins. Globally, variations in stable carbon isotope ratios (delta 13C values) of POC between the upper and lower euphotic zones (LEZ) indicate either varying aspects of photosynthetic communities or degradative alteration of POC. During summertime in the subtropical north Atlantic Ocean, we find that delta 13C values of the photosynthetic product phytol decreased b...
• An evolutionary innovation for mating facilitates ecological niche expansion and buffers species against climate change AI翻译
  作者：Moore, Michael P.; Nalley, Sarah E.; Hamadah, Dalal
  作者单位：University of Colorado System; University of Colorado Denver; University of Colorado Anschutz Medical Campus; Children's Hospital Colorado; Washington University (WUSTL)
  摘要：One of the drivers of life's diversification has been the emergence of evolutionary innovations: The evolution of traits that grant access to underused ecological niches. Since ecological interactions can occur separately from mating, mating-related traits have not traditionally been considered factors in niche evolution. However, in order to persist in their environment, animals need to successfully mate just as much as they need to survive. Innovations that facilitate mating activity may the...
• Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion AI翻译
  作者：Kaestner, Lars; Schlenke, Peter; von Lindern, Marieke; El Nemer, Wassim
  作者单位：Universitatsklinikum des Saarlandes; Saarland University; Medical University of Graz; University of Amsterdam; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite
• Diverse roles of pontine NPS- expressing neurons in sleep regulation AI翻译
  作者：Xing, Lijuan; Zou, Xianlin; Yin, Chen; Webb, John M.; Shi, Guangsen; Ptacek, Louis J.; Fu, Ying- Hui
  作者单位：University of California System; University of California San Francisco; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Neuropeptide S (NPS) was postulated to be a wake- promoting neuropeptide with unknown mechanism, and a mutation in its receptor (NPSR1) causes the short sleep duration trait in humans. We investigated the role of different NPS+ nuclei in sleep/wake regulation. Loss- of- function and chemogenetic studies revealed that NPS+ neurons in the parabrachial nucleus (PB) are wake- promoting, whereas peri-locus coeruleus (peri-LC) NPS+ neurons are not important for sleep/wake modulation. Further, we fou...
• Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation AI翻译
  作者：Molin, Arnaud N.; Contentin, Romain; Angelozzi, Marco; Karvande, Anirudha; Kc, Ranjan; Haseeb, Abdul; Voskamp, Chantal; de Charleroy, Charles; Lefebvre, Veronique
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
  摘要：SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High- throughput assays demonstrate expression of human SOX8 and mouse Sox8 in growth plate cartilage. In situ assays show that Sox8 is expressed at a similar level as Sox9 in reserve and early columnar chondrocytes and turned off when Sox9 expression ...
• Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production AI翻译
  作者：Noch, Evan K.; Palma, Laura; Yim, Isaiah; Bullen, Nayah; Barnett, Daniel; Walsh, Alexander; Bhinder, Bhavneet; Benedetti, Elisa; Krumsiek, Jan; Gurvitch, Justin; Khwaja, Sumaiyah; Atlas, Daphne; Elemento, Olivier; Cantley, Lewis C.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Hebrew University of Jerusalem; Harvard University; Harvard Medical School
  摘要：Glucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are targetable with FDA- approved compounds. To investigate tumor metabolism signatures unique to GBM, we interrogated The Cancer Genome Atlas for alterations in glucose and amino acid signatures in GBM relative to other human cancers and found that GBM exhibits the highest levels of cysteine and methionine pathway gene expression of 32 human ca...
• Dynamic fading memory and expectancy effects in the monkey primary visual cortex AI翻译
  作者：Yang, Yiling; Klon-Lipok, Johanna; Shapcott, Katharine; Lazar, Andreea; Singer, Wolf
  作者单位：Max Planck Society; Max Planck Society
  摘要：In order to investigate the involvement of the primary visual cortex (V1) in working memory (WM), parallel, multisite recordings of multi - unit activity were obtained from monkey V1 while the animals performed a delayed match - to- sample (DMS) task. During the delay period, V1 population firing rate vectors maintained a lingering trace of the sample stimulus that could be reactivated by intervening impulse stimuli that enhanced neuronal firing. This fading trace of the sample did not require...
• Geological evidence of extensive N- fixation by volcanic lightning during very large explosive eruptions AI翻译
  作者：Aroskay, Adeline; Martin, Erwan; Bekki, Slimane; Le Pennec, Jean- Luc; Savarino, Joel; Temel, Abidin; Manrique, Nelida; Aguilar, Rigoberto; Rivera, Marco; Guillou, Herve; Balcone-Boissard, Helene; Phelip, Oceane; Szopa, Sophie
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Universite Paris Saclay; Ifremer; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM); Institut de Recherche pour le Developpement (IRD); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Hacettepe University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU)
  摘要：Most of the nitrogen (N) accessible for life is trapped in dinitrogen (N2), the most stable atmospheric molecule. In order to be metabolized by living organisms, N2 has to be converted into biologically assimilable forms, so - called fixed N. Nowadays, nearly all the N- fixation is achieved through biological and anthropogenic processes. However, in early prebiotic environments of the Earth, N- fixation must have occurred via natural abiotic processes. One of the most invoked processes is elec...