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作者：Singh, Parminder; Gollapalli, Kishore; Mangiola, Stefano; Schranner, Daniela; Yusuf, Mohd Aslam; Chamoli, Manish; Shi, Sting L.; Bastos, Bruno Lopes; Nair, Tripti; Riermeier, Annett; Vayndorf, Elena M.; Wu, Judy Z.; Nilakhe, Aishwarya; Nguyen, Christina Q.; Muir, Michael; Kiflezghi, Michael G.; Foulger, Anna; Junker, Alex; Devine, Jack; Sharan, Kunal; Chinta, Shankar J.; Rajput, Swati; Rane, Anand; Baumert, Philipp; Schoenfelder, Martin; Iavarone, Francescopaolo; di Lorenzo, Giorgia; Kumari, Swati; Gupta, Alka; Sarkar, Rajesh; Khyriem, Costerwell; Chawla, Amanpreet S.; Sharma, Ankur; Sarper, Nazan; Chattopadhyay, Naibedya; Biswal, Bichitra K.; Settembre, Carmine; Nagarajan, Perumal; Targoff, Kimara L.; Picard, Martin; Gupta, Sarika; Velagapudi, Vidya; Papenfuss, Anthony T.; Kaya, Alaattin; Ferreira, Miguel Godinho; Kennedy, Brian K.; Andersen, Julie K.; Lithgow, Gordon J.; Ali, Abdullah Mahmood; Mukhopadhyay, Arnab; Palotie, Aarno; Kastenmueller, Gabi; Kaeberlein, Matt; Wackerhage, Henning; Pal, Bhupinder; Yadav, Vijay K.
作者单位：Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Columbia University; Walter & Eliza Hall Institute; University of Melbourne; La Trobe University; La Trobe University; Olivia Newton-John Cancer Research Institute; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Integral University; Buck Institute for Research on Aging; Universite Cote d'Azur; Institut National de la Sante et de la Recherche Medicale (Inserm); Department of Biotechnology (DBT) India; National Institute of Immunology (NII); University of Washington; University of Washington Seattle; Columbia University; Wellcome Trust Sanger Institute; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI); Fondazione Telethon; Telethon Institute of Genetics & Medicine (TIGEM); Harry Perkins Institute of Medical Research; Curtin University; Department of Biotechnology (DBT) India; National Institute of Immunology (NII); University of Dundee; Kocaeli University; University of Naples Federico II; Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Columbia University; University of Helsinki; Virginia Commonwealth University; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Columbia University; Columbia University; University of California System; University of California Santa Barbara
摘要：Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dys...
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作者：Fidelle, Marine; Rauber, Conrad; Silva, Carolina Alves Costa; Tian, Ai-Ling; Lahmar, Imran; de La Varende, Anne-Laure Mallard; Zhao, Liwei; Thelemaque, Cassandra; Lebhar, Isabelle; Messaoudene, Meriem; Pizzato, Eugenie; Birebent, Roxanne; Fonkou, Maxime Descartes Mbogning; Zoppi, Silvia; Reni, Anna; Dalban, Cecile; Leduc, Marion; Ferrere, Gladys; Durand, Sylvere; Ly, Pierre; Silvin, Aymeric; Mulder, Kevin; Dutertre, Charles-Antoine; Ginhoux, Florent; Yonekura, Satoru; Roberti, Maria Paula; Tidjani-Alou, Maryam; Terrisse, Safae; Chen, Jianzhou; Kepp, Oliver; Schippers, Angela; Wagner, Norbert; Suarez-Gosalvez, Javier; Kobold, Sebastian; Fahrner, Jean-Eudes; Richard, Corentin; Bosq, Jacques; Lordello, Leonardo; Vitali, Giacomo; Galleron, Nathalie; Quinquis, Benoit; Le Chatelier, Emmanuelle; Blanchard, Lucas; Girard, Jean-Philippe; Jarry, Anne; Gervois, Nadine; Godefroy, Emmanuelle; Labarriere, Nathalie; Koschny, Ronald; Daillere, Romain; Besse, Benjamin; Truntzer, Caroline; Ghiringhelli, Francois; Coatnoan, Nicolas; Mhanna, Vanessa; Klatzmann, David; Drubay, Damien; Albiges, Laurence; Thomas, Andrew Maltez; Segata, Nicola; Danlos, Francois-Xavier; Marabelle, Aurelien; Routy, Bertrand; Derosa, Lisa; Kroemer, Guido; Zitvogel, Laurence
作者单位：UNICANCER; Gustave Roussy; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Ruprecht Karls University Heidelberg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Sorbonne Universite; UNICANCER; Gustave Roussy; Universite de Montreal; University of Parma; University of Verona; University of Verona; Azienda Ospedaliera Universitaria Integrata Verona; UNICANCER; Centre Leon Berard; UNICANCER; Gustave Roussy; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; National Center for Tumor Diseases; RWTH Aachen University; RWTH Aachen University Hospital; University of Munich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Universite Paris Saclay; INRAE; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite d'Angers; Centre National de la Recherche Scientifique (CNRS); Nantes Universite; Nantes Universite; Institut Agro; AgroSup Dijon; UNICANCER; Universite Bourgogne Europe; Centre Georges-Francois Leclerc; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite Paris Saclay; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; University of Trento; IRCCS European Institute of Oncology (IEO); UNICANCER; Gustave Roussy; Universite de Montreal; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP
摘要：Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. By inducing the down-regulation of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in the ileum, post-ABX gut recolonization by Enterocloster species drove the emigration of enterotropic a4b7+CD4+ regulatory T 17 cells into the tumor. These deleterious ABX effects were mimicked by oral gavage of Ente...
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作者：Townshend, R. J. L.
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作者：Kelly, Patrick L.; Rodney, Steven; Treu, Tommaso; Oguri, Masamune; Chen, Wenlei; Zitrin, Adi; Birrer, Simon; Bonvin, Vivien; Dessart, Luc; Diego, Jose M.; Filippenko, Alexei V.; Foley, Ryan J.; Gilman, Daniel; Hjorth, Jens; Jauzac, Mathilde; Mandel, Kaisey; Millon, Martin; Pierel, Justin; Sharon, Keren; Thorp, Stephen; Williams, Liliya; Broadhurst, Tom; Dressler, Alan; Graur, Or; Jha, Saurabh; McCully, Curtis; Postman, Marc; Schmidt, Kasper Borello; Tucker, Brad E.; von der Linden, Anja
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of South Carolina System; University of South Carolina Columbia; University of California System; University of California Los Angeles; Chiba University; University of Tokyo; University of Tokyo; Ben-Gurion University of the Negev; Stanford University; State University of New York (SUNY) System; Stony Brook University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Cantabria; CSIC - Instituto de Fisica de Cantabria (IFCA); Universidad de Cantabria; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Santa Cruz; University of Toronto; University of Copenhagen; Niels Bohr Institute; Durham University; Durham University; University of Kwazulu Natal; University of Kwazulu Natal; University of Cambridge; University of Cambridge; University of Cambridge; Space Telescope Science Institute; University of Michigan System; University of Michigan; Stockholm University; Oskar Klein Centre; Basque Foundation for Science; University of Basque Country; Carnegie Institution for Science; University of Portsmouth; American Museum of Natural History (AMNH); Rutgers University System; Rutgers University New Brunswick; University of California System; University of California Santa Barbara; Leibniz Association; Leibniz Institut fur Astrophysik Potsdam (AIP); Australian National University; Australian National University
摘要：The gravitationally lensed supernova Refsdal appeared in multiple images produced through gravitational lensing by a massive foreground galaxy cluster. After the supernova appeared in 2014, lens models of the galaxy cluster predicted that an additional image of the supernova would appear in 2015, which was subsequently observed. We use the time delays between the images to perform a blinded measurement of the expansion rate of the Universe, quantified by the Hubble constant (H-0). Using eight ...
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作者：Erwin, G. S.
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作者：Pang, Yue; Noethling, Nils; Leutzsch, Markus; Kang, Liqun; Bill, Eckhard; van Gastel, Maurice; Reijerse, Edward; Goddard, Richard; Wagner, Lucas; SantaLucia, Daniel; DeBeer, Serena; Neese, Frank; Cornella, Josep
作者单位：Max Planck Society; Max Planck Society
摘要：Large spin-orbit coupling (SOC) is an intrinsic property of the heavy elements that directly affects the electronic structures of the compounds. In this work, we report the synthesis and characterization of a monocoordinate bismuthinidene that features a rigid and bulky ligand. All magnetic measurements [superconducting quantum interference device (SQUID), nuclear magnetic resonance (NMR)] point to a diamagnetic compound. However, multiconfigurational quantum chemical calculations predict the ...
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作者：Sierda, E.; Huang, X.; Badrtdinov, D. I.; Kiraly, B.; Knol, E. J.; Groenenboom, G. C.; Katsnelson, M. I.; Rosner, M.; Wegner, D.; Khajetoorians, A. A.
作者单位：Radboud University Nijmegen
摘要：Bottom-up quantum simulators have been developed to quantify the role of various interactions, dimensionality, and structure in creating electronic states of matter. Here, we demonstrated a solid-state quantum simulator emulating molecular orbitals, based solely on positioning individual cesium atoms on an indium antimonide surface. Using scanning tunneling microscopy and spectroscopy, combined with ab initio calculations, we showed that artificial atoms could be made from localized states cre...
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作者：Bibi, Faysal; Cantalapiedra, Juan L.
作者单位：Leibniz Institut fur Evolutions und Biodiversitatsforschung; Universidad de Alcala
摘要：Fossil abundance data can reveal ecological dynamics underpinning taxonomic declines. Using fossil dental metrics, we reconstructed body mass and mass-abundance distributions in Late Miocene to recent African large mammal communities. Despite collection biases, fossil and extant mass-abundance distributions are highly similar, with unimodal distributions likely reflecting savanna environments. Above 45 kilograms, abundance decreases exponentially with mass, with slopes close to -0.75, as predi...
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作者：Zholdassov, Yerzhan S.; Yuan, Li; Garcia, Sergio Romero; Kwok, Ryan W.; Boscoboinik, Alejandro; Valles, Daniel J.; Marianski, Mateusz; Martini, Ashlie; Carpick, Robert W.; Braunschweig, Adam B.
作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; Hunter College (CUNY); City University of New York (CUNY) System; University of Pennsylvania; University of California System; University of California Merced
摘要：Challenges in quantifying how force affects bond formation have hindered the widespread adoption of mechanochemistry. We used parallel tip-based methods to determine reaction rates, activation energies, and activation volumes of force-accelerated [4+2] Diels-Alder cycloadditions between surface-immobilized anthracene and four dienophiles that differ in electronic and steric demand. The rate dependences on pressure were unexpectedly strong, and substantial differences were observed between the ...
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作者：Calderon, V. Sebastian; Hayden, John; Baksa, Steven M.; Tzou, William; Trolier-McKinstry, Susan; Dabo, Ismaila; Maria, Jon -Paul; Dickey, Elizabeth C.
作者单位：Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Ferroelectric wurtzites have the potential to revolutionize modern microelectronics because they are easily integrated with multiple mainstream semiconductor platforms. However, the electric fields required to reverse their polarization direction and unlock electronic and optical functions need substantial reduction for operational compatibility with complementary metal-oxide semiconductor (CMOS) electronics. To understand this process, we observed and quantified real-time polarization switchi...
