Taurine deficiency as a driver of aging

• 成果类型: Article
• 署名作者: Singh, Parminder; Gollapalli, Kishore; Mangiola, Stefano; Schranner, Daniela; Yusuf, Mohd Aslam; Chamoli, Manish; Shi, Sting L.; Bastos, Bruno Lopes; Nair, Tripti; Riermeier, Annett; Vayndorf, Elena M.; Wu, Judy Z.; Nilakhe, Aishwarya; Nguyen, Christina Q.; Muir, Michael; Kiflezghi, Michael G.; Foulger, Anna; Junker, Alex; Devine, Jack; Sharan, Kunal; Chinta, Shankar J.; Rajput, Swati; Rane, Anand; Baumert, Philipp; Schoenfelder, Martin; Iavarone, Francescopaolo; di Lorenzo, Giorgia; Kumari, Swati; Gupta, Alka; Sarkar, Rajesh; Khyriem, Costerwell; Chawla, Amanpreet S.; Sharma, Ankur; Sarper, Nazan; Chattopadhyay, Naibedya; Biswal, Bichitra K.; Settembre, Carmine; Nagarajan, Perumal; Targoff, Kimara L.; Picard, Martin; Gupta, Sarika; Velagapudi, Vidya; Papenfuss, Anthony T.; Kaya, Alaattin; Ferreira, Miguel Godinho; Kennedy, Brian K.; Andersen, Julie K.; Lithgow, Gordon J.; Ali, Abdullah Mahmood; Mukhopadhyay, Arnab; Palotie, Aarno; Kastenmueller, Gabi; Kaeberlein, Matt; Wackerhage, Henning; Pal, Bhupinder; Yadav, Vijay K.
• 署名单位: Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Columbia University; Walter & Eliza Hall Institute; University of Melbourne; La Trobe University; La Trobe University; Olivia Newton-John Cancer Research Institute; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Integral University; Buck Institute for Research on Aging; Universite Cote d'Azur; Institut National de la Sante et de la Recherche Medicale (Inserm); Department of Biotechnology (DBT) India; National Institute of Immunology (NII); University of Washington; University of Washington Seattle; Columbia University; Wellcome Trust Sanger Institute; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI); Fondazione Telethon; Telethon Institute of Genetics & Medicine (TIGEM); Harry Perkins Institute of Medical Research; Curtin University; Department of Biotechnology (DBT) India; National Institute of Immunology (NII); University of Dundee; Kocaeli University; University of Naples Federico II; Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Columbia University; University of Helsinki; Virginia Commonwealth University; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Columbia University; Columbia University; University of California System; University of California Santa Barbara
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8224
• DOI: 10.1126/science.abn9257
• 发表日期: 2023-06-09
• 关键词: amino-acid-concentrations; gene-expression; stem-cells; plasma; bone; metabolomics; transporter; pathways; identification; reproduction

摘要

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.