-
作者：Bowman, Adam J.; Huang, Cheng; Schnitzer, Mark J.; Kasevich, Mark A.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Washington University (WUSTL)
摘要：The development of voltage-sensitive fluorescent probes suggests fluorescence lifetime as a promising readout for electrical activity in biological systems. Existing approaches fail to achieve the speed and sensitivity required for voltage imaging in neuroscience applications. We demonstrated that wide-field electro-optic fluorescence lifetime imaging microscopy (EO-FLIM) allows lifetime imaging at kilohertz frame-acquisition rates, spatially resolving action potential propagation and subthres...
-
作者：Kiefer, Lea; Chiosso, Anna; Langen, Jennifer; Buckley, Alex; Gaudin, Simon; Rajkumar, Sandy M.; Servito, Gabrielle Isabelle F.; Cha, Elizabeth S.; Vijay, Akshara; Yeung, Albert; Horta, Adan; Mui, Michael H.; Canzio, Daniele
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Ecole Normale Superieure de Lyon (ENS de LYON); University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
摘要：Neural type-specific expression of clustered Protocadherin (Pcdh) proteins is essential for the establishment of connectivity patterns during brain development. In mammals, deterministic expression of the same Pcdh isoform promotes minimal overlap of tiled projections of serotonergic neuron axons throughout the brain, while stochastic expression of Pcdh genes allows for convergence of tightly packed, overlapping olfactory sensory neuron axons into targeted structures. How can the same gene loc...
-
作者：Service, Robert F.
-
作者：Brainard, Jeffrey
-
作者：Kelly-Bellow, Robert; Lee, Karen; Kennaway, Richard; Barclay, J. Elaine; Whibley, Annabel; Bushell, Claire; Spooner, Jamie; Yu, Man; Brett, Paul; Kular, Baldeep; Cheng, Shujing; Chu, Jinfang; Xu, Ting; Lane, Brendan; Fitzsimons, James; Xue, Yongbiao; Smith, Richard S.; Whitewoods, Christopher D.; Coen, Enrico
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of Cambridge
摘要：Growth coordination between cell layers is essential for development of most multicellular organisms. Coordination may be mediated by molecular signaling and/or mechanical connectivity between cells, but how genes modify mechanical interactions between layers is unknown. Here we show that genes driving brassinosteroid synthesis promote growth of internal tissue, at least in part, by reducing mechanical epidermal constraint. We identified a brassinosteroid-deficient dwarf mutant in the aquatic ...
-
作者：Yazdani, Ali; von Oppen, Felix; Halperin, Bertrand I.; Yacoby, Amir
作者单位：Princeton University; Princeton University; Free University of Berlin; Harvard University
摘要：Over the past decade, there have been considerable efforts to observe non-abelian quasiparticles in novel quantum materials and devices. These efforts are motivated by the goals of demonstrating quantum statistics of quasiparticles beyond those of fermions and bosons and of establishing the underlying science for the creation of topologically protected quantum bits. In this Review, we focus on efforts to create topological superconducting phases that host Majorana zero modes. We consider the l...
-
作者：Heidt, Amanda
-
作者：Brainard, Jeffrey
-
作者：Wang, Shu; Hu, Yixin; Kouznetsova, Tatiana B.; Sapir, Liel; Chen, Danyang; Herzog-Arbeitman, Abraham; Johnson, Jeremiah A.; Rubinstein, Michael; Craig, Stephen L.
作者单位：Duke University; Duke University; Duke University; Duke University; Duke University; Hokkaido University; Massachusetts Institute of Technology (MIT)
摘要：The mechanical properties of covalent polymer networks often arise from the permanent end-linking or cross-linking of polymer strands, and molecular linkers that break more easily would likely produce materials that require less energy to tear. We report that cyclobutane-based mechanophore cross-linkers that break through force-triggered cycloreversion lead to networks that are up to nine times as tough as conventional analogs. The response is attributed to a combination of long, strong primar...
-
作者：Zhu, Kai; Cheng, Yufeng; Zhou, Quan
作者单位：Hubei University
