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作者：[Anonymous]
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作者：Franklin, Alan B.
作者单位：United States Department of Agriculture (USDA)
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作者：Naon, Deborah; Hernandez-Alvarez, Maria Isabel; Shinjo, Satoko; Wieczor, Milosz; Ivanova, Saska; Martins de Brito, Olga; Quintana, Albert; Hidalgo, Juan; Palacin, Manuel; Aparicio, Pilar; Castellanos, Juan; Lores, Luis; Sebastian, David; Fernandez-Veledo, Sonia; Vendrell, Joan; Joven, Jorge; Orozco, Modesto; Zorzano, Antonio; Scorrano, Luca
作者单位：University of Padua; Veneto Institute Molecular Medicine; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; University of Barcelona; Fahrenheit Universities; Gdansk University of Technology; Autonomous University of Barcelona; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Instituto de Salud Carlos III; Universitat Rovira i Virgili; Hospital Universitari De Tarragona Joan XXIII; Universitat Rovira i Virgili; Universitat Rovira i Virgili
摘要：In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology, whereas ERMIT2 localized at the ER-mitochondria interface and inte...
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作者：Clery, Daniel
摘要：A European space telescope sets off to discover the nature of dark energy-the biggest ingredient in the universe
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作者：Gamerdinger, Martin; Jia, Min; Schloemer, Renate; Rabl, Laurenz; Jaskolowski, Mateusz; Khakzar, Katrin M.; Ulusoy, Zeynel; Wallisch, Annalena; Jomaa, Ahmad; Hunaeus, Gundula; Scaiola, Alain; Diederichs, Kay; Ban, Nenad; Deuerling, Elke
作者单位：University of Konstanz; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Konstanz
摘要：N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally by methionine aminopeptidases (METAPs), is an essential and universally conserved process that plays a key role in cell homeostasis and protein biogenesis. However, how METAPs interact with ribosomes and how their cleavage specificity is ensured is unknown. We discovered that in eukaryotes the nascent polypeptide-associated complex (NAC) controls ribosome binding of METAP1. NAC recruits METAP1 using a l...
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作者：[Anonymous]
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作者：Rodriguez-Silvestre, Pablo; Laub, Marco; Krawczyk, Patrycja A.; Davies, Alexandra K.; Schessner, Julia P.; Parveen, Reejuana; Tuck, Benjamin J.; McEwan, William A.; Borner, Georg H. H.; Kozik, Patrycja
作者单位：MRC Laboratory Molecular Biology; Max Planck Society; University of Cambridge; University of Manchester
摘要：During initiation of antiviral and antitumor T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on major histocompatibility complex (MHC) class I molecules. Cross-presentation relies on the unusual leakiness of endocytic compartments in DCs, whereby internalized proteins escape into the cytosol for proteasome-mediated generation of MHC I-binding peptides. Given that type 1 conventional DCs excel at cross-presentation, we searched for cell type-specific eff...
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作者：Shen, Lei
作者单位：Yale University
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作者：Cho, Adrian
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作者：Rillig, Matthias C.; Bank, Michael S.; Maass, Stefanie; Roger, Melia; Maeder, Marcus
作者单位：Free University of Berlin; Institute of Marine Research - Norway; University of Massachusetts System; University of Massachusetts Amherst; University of Zurich
