-
作者：Gonzalez-Bailon, Sandra; Lazer, David
作者单位：University of Pennsylvania; Northeastern University
-
作者：Stokstad, Erik
-
作者：Yao, N.; Zhang, Z.; Yu, L.; Hazarika, R.; Yu, C.; Jang, H.; Smith, L. M.; Ton, J.; Liu, L.; Stachowicz, J. J.; Reusch, T. B. H.; Schmitz, R. J.; Johannes, F.
作者单位：University System of Georgia; University of Georgia; Technical University of Munich; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; University of Sheffield; University System of Georgia; University of Georgia; University of California System; University of California Davis
摘要：Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (similar to 10(5) to 10(8) years). However, classical DNA-based clocks tick too slowly to inform us about the recent past. Here, we demonstrate that stochastic DNA methylation changes at a subset of cytosines in plant genomes display a clocklike behavior. This epimutation clock is orders of magnitude faster than DNA-based clocks and enables phylogenetic explorations on a scale of years t...
-
作者：Camelliti, Patrizia; Stuckey, Daniel J.
作者单位：University of Surrey; University of London; University College London
-
作者：Enbody, Erik D.; Sendell-Price, Ashley T.; Sprehn, C. Grace; Rubin, Carl-Johan; Visscher, Peter M.; Grant, B. Rosemary; Grant, Peter R.; Andersson, Leif
作者单位：Uppsala University; University of Queensland; Princeton University; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Santa Cruz; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：A fundamental goal in evolutionary biology is to understand the genetic architecture of adaptive traits. Using whole-genome data of 3955 of Darwin's finches on the Galapagos Island of Daphne Major, we identified six loci of large effect that explain 45% of the variation in the highly heritable beak size of Geospiza fortis, a key ecological trait. The major locus is a supergene comprising four genes. Abrupt changes in allele frequencies at the loci accompanied a strong change in beak size cause...
-
作者：Rahimzadeh, Vasiliki; Fogarty, Jennifer; Caulfield, Timothy; Aunon-Chancellor, Serena; Borry, Pascal; Candia, Jessica; Cohen, I. Glenn; Covington, Marisa; Lynch, Holly Fernandez; Greely, Henry T.; Hanlon, Michelle; Hatt, James; Low, Lucie; Menikoff, Jerry; Meslin, Eric M.; Platts, Steven; Ravitsky, Vardit; Ruttley, Tara; Seidler, Rachael D.; Sugarman, Jeremy; Urquieta, Emmanuel; Williams, Michael A.; Wolpe, Paul Root; Donoviel, Dorit; McGuire, Amy L.
作者单位：Baylor College of Medicine; Baylor College of Medicine; University of Alberta; University of Alberta; Louisiana State University System; Louisiana State University Health Sciences Center at Shreveport; Louisiana State University; KU Leuven; Harvard University; National Aeronautics & Space Administration (NASA); University of Pennsylvania; Stanford University; University of Mississippi; National University of Singapore; National Aeronautics & Space Administration (NASA); Universite de Montreal; Harvard University; Harvard Medical School; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Johns Hopkins University; Johns Hopkins University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Emory University
-
作者：Santana, Darian J.; Anku, Juliet A. E.; Zhao, Guolei; Zarnowski, Robert; Johnson, Chad J.; Hautau, Haley; Visser, Noelle D.; Ibrahim, Ashraf S.; Andes, David; Nett, Jeniel E.; Singh, Shakti; O'Meara, Teresa R.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Ghana; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Louisville
摘要：Candida auris is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by C. auris and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. SCF1 is apparently specific to C. auris, and its expression mediates adhesion to inert and biolo...
-
作者：Thorp, H. Holden
摘要：Science is fortunate that so many authors seek to publish with us. We shoulder enormous responsibility from both our outsized influence on research across many fields and from the journal's impact on the careers of scientists who publish in our pages. Although there can be some cynicism about the role of highly selective glam journals, we understand why we are part of conversations that sometimes center around CNS (Cell, Nature, Science) periodicals. All three have considerable importance and ...
-
作者：Price, Michael
-
作者：Kupferschmidt, Kai
