A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence

• 成果类型: Article
• 署名作者: Santana, Darian J.; Anku, Juliet A. E.; Zhao, Guolei; Zarnowski, Robert; Johnson, Chad J.; Hautau, Haley; Visser, Noelle D.; Ibrahim, Ashraf S.; Andes, David; Nett, Jeniel E.; Singh, Shakti; O'Meara, Teresa R.
• 署名单位: University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Ghana; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Louisville
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12915
• DOI: 10.1126/science.adf8972
• 发表日期: 2023-09-29
• 页码: 1461-1467
• 关键词: UNITED-STATES; lysine

摘要

Candida auris is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by C. auris and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. SCF1 is apparently specific to C. auris, and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association. SCF1 is required for C. auris biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.