作者：Cooper, Robert M.; Wright, Josephine A.; Ng, Jia Q.; Goyne, Jarrad M.; Suzuki, Nobumi; Lee, Young K.; Ichinose, Mari; Radford, Georgette; Ryan, Feargal J.; Kumar, Shalni; Thomas, Elaine M.; Vrbanac, Laura; Knight, Rob; Woods, Susan L.; Worthley, Daniel L.; Hasty, Jeff
作者单位：University of California System; University of California San Diego; University of Adelaide; Flinders University South Australia; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Synthetic biology has developed sophisticated cellular biosensors to detect and respond to human disease. However, biosensors have not yet been engineered to detect specific extracellular DNA sequences and mutations. Here, we engineered naturally competent Acinetobacter baylyi to detect donor DNA from the genomes of colorectal cancer (CRC) cells, organoids, and tumors. We characterized the functionality of the biosensors in vitro with coculture assays and then validated them in vivo with senso...
作者：Bowman, David M. J. S.; Sharples, Jason J.
作者单位：University of Tasmania; University of New South Wales Sydney
作者：Legge, Sarah; Rumpff, Libby; Garnett, Stephen T.; Woinarski, John C. Z.
作者单位：Charles Darwin University; Australian National University; University of Melbourne
摘要：Australia's biota is species rich, with high rates of endemism. This natural legacy has rapidly diminished since European colonization. The impacts of invasive species, habitat loss, altered fire regimes, and changed water flows are now compounded by climate change, particularly through extreme drought, heat, wildfire, and flooding. Extinction rates, already far exceeding the global average for mammals, are predicted to escalate across all taxa, and ecosystems are collapsing. These losses are ...
作者：Yang, Qiying; Yang, Shanshan
作者单位：China University of Geosciences; China University of Geosciences
作者：Horwitz, Rick
作者单位：University of Virginia; University of Virginia
