2023

最新文章

• Genetic circuitry boosts cell longevity AI翻译
  作者：Salis, Howard M.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
• From pipelines to pathways in the study of academic progress AI翻译
  作者：Kizilcec, Rene F.; Baker, Rachel B.; Bruch, Elizabeth; Cortes, Kalena E.; Hamilton, Laura T.; Lang, David Nathan; Pardos, Zachary A.; Thompson, Marissa E.; Stevens, Mitchell L.
  作者单位：Cornell University; University of Pennsylvania; University of Michigan System; University of Michigan; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Merced; University of California System; University of California Berkeley; Columbia University; Stanford University
• Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs AI翻译
  作者：Moon, Katherine L.; Huson, Heather J.; Morrill, Kathleen; Wang, Ming-Shan; Li, Xue; Srikanth, Krishnamoorthy; Lindblad-Toh, Kerstin; Svenson, Gavin J.; Karlsson, Elinor K.; Shapiro, Beth
  作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz; Howard Hughes Medical Institute; Cornell University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Uppsala University; Cleveland Museum of Natural History
  摘要：We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enha...
• Biden to nominate Monica Bertagnolli to lead NIH The NCI director and surgical oncologist would fill a 16-month vacancy AI翻译
  作者：Mervis, Jeffrey
• Uganda's antigay law protested AI翻译
  作者：[Anonymous]
• Making protected areas in the high seas count AI翻译
  作者：Claudet, Joachim; Brooks, Cassandra M.; Blasiak, Robert
  作者单位：Universite PSL; Centre National de la Recherche Scientifique (CNRS); University of Colorado System; University of Colorado Boulder; Stockholm University; University of Tokyo
• Astronomers home in on colliding giant black hole duos AI翻译
  作者：Clery, Daniel
• Three-dimensional genome rewiring in loci with human accelerated regions AI翻译
  作者：Keough, Kathleen C.; Whalen, Sean; Inoue, Fumitaka; Przytycki, Pawel F.; Fair, Tyler; Deng, Chengyu; Steyert, Marilyn; Ryu, Hane; Lindblad-Toh, Kerstin; Karlsson, Elinor; Nowakowski, Tomasz; Ahituv, Nadav; Pollen, Alex; Pollard, Katherine S.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Uppsala University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); Kyoto University; Boston University
  摘要：Human accelerated regions (HARs) are conserved genomic loci that evolved at an accelerated rate in the human lineage and may underlie human-specific traits. We generated HARs and chimpanzee accelerated regions with an automated pipeline and an alignment of 241 mammalian genomes. Combining deep learning with chromatin capture experiments in human and chimpanzee neural progenitor cells, we discovered a significant enrichment of HARs in topologically associating domains containing human -specific...
• Panel urges caution in tying social, behavioral traits to genes Experts split on whether risks of perpetuating racism mean group comparisons should not be done AI翻译
  作者：Kaiser, Jocelyn
• RAD51 bypasses the CMG helicase to promote replication fork reversal AI翻译
  作者：Liu, Wenpeng; Saito, Yuichiro; Jackson, Jessica; Bhowmick, Rahul; Kanemaki, Masato T.; Vindigni, Alessandro; Cortez, David
  作者单位：Vanderbilt University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Washington University (WUSTL); Graduate University for Advanced Studies - Japan; University of Tokyo; Memorial Sloan Kettering Cancer Center
  摘要：Replication fork reversal safeguards genome integrity as a replication stress response. DNA translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown why RAD51 is required and what happens to the replication machinery during reversal. We find that RAD51 uses its strand exchange activity to circumvent the replicative helicase, which remains bound to the stalled fork. RAD51 is not required for fork reversal if the helicase is unloaded. Thus, we propose that RAD51 crea...