作者：Sun, Chao; Desch, Kristina; Nassim-Assir, Belquis; Giandomenico, Stefano L.; Nemcova, Paulina; Langer, Julian D.; Schuman, Erin M.
作者单位：Max Planck Society; Max Planck Society; Aarhus University; University of Bonn
摘要：The proteasome, the major protein-degradation machine in cells, regulates neuronal synapses and long-term information storage. Here, using super-resolution microscopy, we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles, are differentially distributed within individual rat cortical neurons. We discovered an unexpected abundance of free 19S particles near synapses. The free neuronal 19S particles bind and deubiquitylate lysine 63-ub...
作者：Chung, In
作者单位：Seoul National University (SNU); Institute for Basic Science - Korea (IBS)
摘要：A thermoelectric alloy achieves high performance in electronic cooling
作者：Chmura, Helen E.; Duncan, Cassandra; Burrell, Grace; Barnes, Brian M.; Buck, C. Loren; Williams, Cory T.
作者单位：University of Alaska System; University of Alaska Fairbanks; United States Department of Agriculture (USDA); United States Forest Service; University of Alaska System; University of Alaska Fairbanks; Northern Arizona University; Colorado State University System; Colorado State University Fort Collins
摘要：Climate warming is rapid in the Arctic, yet impacts to biological systems are unclear because few long-term studies linking biophysiological processes with environmental conditions exist for this data-poor region. In our study spanning 25 years in the Alaskan Arctic, we demonstrate that climate change is affecting the timing of freeze-thaw cycles in the active layer of permafrost soils and altering the physiology of arctic ground squirrels (Urocitellus parryii). Soil freeze has been delayed an...
作者：Daehn, Katrin
作者单位：Massachusetts Institute of Technology (MIT)
摘要：An expansive history offers insights into the abundant metal's many facets
