2023

最新文章

• Open-access funders cut journals AI翻译
  作者：[Anonymous]
• Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells AI翻译
  作者：Rodriguez-Silvestre, Pablo; Laub, Marco; Krawczyk, Patrycja A.; Davies, Alexandra K.; Schessner, Julia P.; Parveen, Reejuana; Tuck, Benjamin J.; McEwan, William A.; Borner, Georg H. H.; Kozik, Patrycja
  作者单位：MRC Laboratory Molecular Biology; Max Planck Society; University of Cambridge; University of Manchester
  摘要：During initiation of antiviral and antitumor T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on major histocompatibility complex (MHC) class I molecules. Cross-presentation relies on the unusual leakiness of endocytic compartments in DCs, whereby internalized proteins escape into the cytosol for proteasome-mediated generation of MHC I-binding peptides. Given that type 1 conventional DCs excel at cross-presentation, we searched for cell type-specific eff...
• Three labs in three years AI翻译
  作者：Shen, Lei
  作者单位：Yale University
• Infrastructure woes could slow South Pole experiments AI翻译
  作者：Cho, Adrian
• Sound stewardship for a noisy planet AI翻译
  作者：Rillig, Matthias C.; Bank, Michael S.; Maass, Stefanie; Roger, Melia; Maeder, Marcus
  作者单位：Free University of Berlin; Institute of Marine Research - Norway; University of Massachusetts System; University of Massachusetts Amherst; University of Zurich
• Wide-field fluorescence lifetime imaging of neuron spiking and subthreshold activity in vivo AI翻译
  作者：Bowman, Adam J.; Huang, Cheng; Schnitzer, Mark J.; Kasevich, Mark A.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Washington University (WUSTL)
  摘要：The development of voltage-sensitive fluorescent probes suggests fluorescence lifetime as a promising readout for electrical activity in biological systems. Existing approaches fail to achieve the speed and sensitivity required for voltage imaging in neuroscience applications. We demonstrated that wide-field electro-optic fluorescence lifetime imaging microscopy (EO-FLIM) allows lifetime imaging at kilohertz frame-acquisition rates, spatially resolving action potential propagation and subthres...
• WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring AI翻译
  作者：Kiefer, Lea; Chiosso, Anna; Langen, Jennifer; Buckley, Alex; Gaudin, Simon; Rajkumar, Sandy M.; Servito, Gabrielle Isabelle F.; Cha, Elizabeth S.; Vijay, Akshara; Yeung, Albert; Horta, Adan; Mui, Michael H.; Canzio, Daniele
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Ecole Normale Superieure de Lyon (ENS de LYON); University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
  摘要：Neural type-specific expression of clustered Protocadherin (Pcdh) proteins is essential for the establishment of connectivity patterns during brain development. In mammals, deterministic expression of the same Pcdh isoform promotes minimal overlap of tiled projections of serotonergic neuron axons throughout the brain, while stochastic expression of Pcdh genes allows for convergence of tightly packed, overlapping olfactory sensory neuron axons into targeted structures. How can the same gene loc...
• Could chatbots help devise the next pandemic virus? AI翻译
  作者：Service, Robert F.
• A push for mechanochemistry AI翻译
  作者：Weiss, Paul S.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
• UK shakes up evaluation rubric AI翻译
  作者：Brainard, Jeffrey