2023

最新文章

• Fauci to join Georgetown faculty AI翻译
  作者：Warren, Matthew; Price, Michael
• Frozen in time AI翻译
  作者：Cornwall, Warren
• Response to Comment on The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains AI翻译
  作者：Strausfeld, Nicholas J.; Hou, Xianguang; Sayre, Marcel E.; Hirth, Frank
• NEUROSCIENCE Consciousness hunt yields results but not clarity AI翻译
  作者：Finkel, Elizabeth
• Spatially resolved single-cell translatomics at molecular resolution AI翻译
  作者：Zeng, Hu; Huang, Jiahao; Ren, Jingyi; Wang, Connie Kangni; Tang, Zefang; Zhou, Haowen; Zhou, Yiming; Shi, Hailing; Aditham, Abhishek; Sui, Xin; Chen, Hongyu; Lo, Jennifer A.; Wang, Xiao
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT)
  摘要：The precise control of messenger RNA (mRNA) translation is a crucial step in posttranscriptional gene regulation of cellular physiology. However, it remains a challenge to systematically study mRNA translation at the transcriptomic scale with spatial and single-cell resolution. Here, we report the development of ribosome-bound mRNA mapping (RIBOmap), a highly multiplexed three-dimensional in situ profiling method to detect cellular translatome. RIBOmap profiling of 981 genes in HeLa cells reve...
• US OKs sale of lab-grown chicken AI翻译
  作者：Warren, Matthew; Price, Michael
• The Three Ages of Water: Prehistoric Past, Imperiled Present, and a Hope for the Future AI翻译
  作者：Aczel, Miriam
  作者单位：University of California System; University of California Berkeley
• Not teaching evolution is an injustice AI翻译
  作者：Shashidhara, L. S.; Joshi, Amitabh
  作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR)
• Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1 AI翻译
  作者：Zhang, Tao; Xu, Daichao; Trefts, Elijah; Lv, Mingming; Inuzuka, Hiroyuki; Song, Guobin; Liu, Min; Lu, Jianlin; Liu, Jianping; Chu, Chen; Wang, Min; Wang, Huibing; Meng, Huyan; Liu, Hui; Zhuang, Yuan; Xie, Xingxing; Dang, Fabin; Guan, Dongxian; Men, Yuqin; Jiang, Shuwen; Jiang, Cong; Dai, Xiaoming; Liu, Jing; Wang, Zhen; Yan, Peiqiang; Wang, Jingchao; Tu, Zhenbo; Babuta, Mrigya; Erickson, Emily; Hillis, Alissandra L.; Dibble, Christian C.; Asara, John M.; Szabo, Gyongy; Sicinski, Piotr; Miao, Ji; Lee, Yu-Ru; Pan, Lifeng; Shaw, Reuben J.; Yuan, Junying; Wei, Wenyi
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Harvard University; Harvard Medical School; Salk Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; St Jude Children's Research Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Huazhong University of Science & Technology; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Jinan University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Academia Sinica - Taiwan; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS
  摘要：Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell death are not fully understood. We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, whereas AMPK inhibited RIPK1 by phosphorylation at Ser(415) to suppress energy stress-induced cell death. I...
• Gullies on Mars could have formed by melting of water ice during periods of high obliquity AI翻译
  作者：Dickson, J. L.; Palumbo, A. M.; Head, J. W.; Kerber, L.; Fassett, C. I.; Kreslavsky, M. A.
  作者单位：California Institute of Technology; Brown University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; National Aeronautics & Space Administration (NASA); University of California System; University of California Santa Cruz; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory
  摘要：Gullies on Mars resemble water-carved channels on Earth, but they are mostly at elevations where liquid water is not expected under current climate conditions. It has been suggested that sublimation of carbon dioxide ice alone could have formed Martian gullies. We used a general circulation model to show that the highest-elevation Martian gullies coincide with the boundary of terrain that experienced pressures above the triple point of water when Mars' rotational axis tilt reached 35 degrees. ...