2023

最新文章

• FUNDING US military contract could boost status of Black university AI翻译
  作者：Mervis, Jeffrey
• ECOLOGY Scientists size up human predatory footprint AI翻译
  作者：Warren, Matthew; Price, Michael
• Building a better TB vaccine AI翻译
  作者：Warren, Matthew; Price, Michael
• Border conservation in Hindu Kush-Himalaya AI翻译
  作者：Chen, Xiaodong; Hull, Vanessa
  作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; State University System of Florida; University of Florida
• Agricultural expansion raises groundwater and increases flooding in the South American plains AI翻译
  作者：Houspanossian, Javier; Gimenez, Raul; Whitworth-Hulse, Juan I.; Nosetto, Marcelo D.; Tych, Wlodek; Atkinson, Peter M.; Rufino, Mariana C.; Jobbagy, Esteban G.
  作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis; Lancaster University; Technical University of Munich
  摘要：Regional effects of farming on hydrology are associated mostly with irrigation. In this work, we show how rainfed agriculture can also leave large-scale imprints. The extent and speed of farming expansion across the South American plains over the past four decades provide an unprecedented case of the effects of rainfed farming on hydrology. Remote sensing analysis shows that as annual crops replaced native vegetation and pastures, floods gradually doubled their coverage, increasing their sensi...
• A new class of antiparasitic drugs AI翻译
  作者：Aphasizhev, Ruslan; Aphasizheva, Inna
  作者单位：Boston University
• HIV prevention disparities persist AI翻译
  作者：Warren, Matthew; Price, Michael
• Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome AI翻译
  作者：Brueckner, David B.; Chen, Hongtao; Barinov, Lev; Zoller, Benjamin; Gregor, Thomas
  作者单位：Institute of Science & Technology - Austria; ShanghaiTech University; Princeton University; Memorial Sloan Kettering Cancer Center; Princeton University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS)
  摘要：Chromosomes in the eukaryotic nucleus are highly compacted. However, for many functional processes, including transcription initiation, the pairwise motion of distal chromosomal elements such as enhancers and promoters is essential and necessitates dynamic fluidity. Here, we used a live-imaging assay to simultaneously measure the positions of pairs of enhancers and promoters and their transcriptional output while systematically varying the genomic separation between these two DNA loci. Our ana...
• Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections AI翻译
  作者：Rao, Srinivasa P. S.; Gould, Matthew K.; Noeske, Jonas; Saldivia, Manuel; Jumani, Rajiv S.; Ng, Pearly S.; Rene, Olivier; Chen, Yen-Liang; Kaiser, Marcel; Ritchie, Ryan; Francisco, Amanda Fortes; Johnson, Nila; Patra, Debjani; Cheung, Harry; Deniston, Colin; Schenk, Andreas D.; Cortopassi, Wilian A.; Schmidt, Remo S.; Wiedemar, Natalie; Thomas, Bryanna; Palkar, Rima; Ghafar, Nahdiyah A.; Manoharan, Vanessa; Luu, Catherine; Gable, Jonathan E.; Wan, Kah Fei; Myburgh, Elmarie; Mottram, Jeremy C.; Barnes, Whitney; Walker, John; Wartchow, Charles; Aziz, Natasha; Osborne, Colin; Wagner, Juergen; Sarko, Christopher; Kelly, John M.; Manjunatha, Ujjini H.; Maeser, Pascal; Jiricek, Jan; Lakshminarayana, Suresh B.; Barrett, Michael P.; Diagana, Thierry T.
  作者单位：Novartis; Novartis USA; Novartis; Novartis Singapore; University of Glasgow; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; University of London; London School of Hygiene & Tropical Medicine; Novartis; Novartis USA; Novartis; University of Hull; University of York - UK; University of York - UK
  摘要：Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but Chagas disease therapies rely on two nitroheterocycles, which suffer from lengthy drug regimens and safety concerns that cause frequent treatment discontinuation. We performed phenotypic screening against trypanosomes and identified a class of cyanotriazoles (CTs) with potent trypanocid...
• Windpipe transplanter sentenced AI翻译
  作者：Warren, Matthew; Price, Michael