2023

最新文章

• Studies probe COVID-19 shots' link to rare symptoms AI翻译
  作者：Vogel, Gretchen; Couzin-Frankel, Jennifer
• Cortical polarity ensures its own asymmetric inheritance in the stomatal lineage to pattern the leaf surface AI翻译
  作者：Muroyama, Andrew; Gong, Yan; Hartman, Kensington S.; Bergmann, Dominique C.
  作者单位：Stanford University; University of California System; University of California San Diego; Howard Hughes Medical Institute; Stanford University; Harvard University
  摘要：Asymmetric cell divisions specify differential cell fates across kingdoms. In metazoans, preferential inheritance of fate determinants into one daughter cell frequently depends on polarity-cytoskeleton interactions. Despite the prevalence of asymmetric divisions throughout plant development, evidence for analogous mechanisms that segregate fate determinants remains elusive. Here, we describe a mechanism in the Arabidopsis leaf epidermis that ensures unequal inheritance of a fate-enforcing pola...
• Diet-microbe-host interaction in early life AI翻译
  作者：Stewart, Christopher J.
  作者单位：Newcastle University - UK
  摘要：Breast milk is a complex biofluid crafted over millions of years of evolution to provide optimal nutrition along with other bioactive compounds to the infant. Human milk oligosaccharides (HMOs) are complex sugars that represent the fourth most abundant component of breast milk, which makes them more numerous than proteins and other vital nutrients, yet they provide no direct nutritional benefit to the infant (1). Human evolution does not favor wasteful processes, which suggests that HMOs play ...
• Dearomative ring expansion of thiophenes by bicyclobutane insertion AI翻译
  作者：Wang, Huamin; Shao, Huiling; Das, Ankita; Dutta, Subhabrata; Chan, Hok Tsun; Daniliuc, Constantin; Houk, K. N.; Glorius, Frank
  作者单位：University of California System; University of California Los Angeles
  摘要：Skeletal ring enlargement is gaining renewed interest in synthetic chemistry and has recently focused on insertion of one or two atoms. Strategies for heterocyclic expansion through small-ring insertion remain elusive, although they would lead to the efficient formation of bicyclic products. Here, we report a photoinduced dearomative ring enlargement of thiophenes by insertion of bicyclo[1.1.0]butanes to produce eight-membered bicyclic rings under mild conditions. The synthetic value, broad fu...
• After race ban, other routes to diversity beckon AI翻译
  作者：Mervis, Jeffrey
• Tandems have the power Perovskite-silicon tandem solar cells b reak the 30% efficiency threshold AI翻译
  作者：De Wolf, Stefaan; Aydin, Erkan
  作者单位：King Abdullah University of Science & Technology
  摘要：One way to increase the efficiency of a solar cell is to optimize it to the wide spectrum of sunlight for conversion into electricity. In this vein, a tandem solar cell may comprise a top cell that absorbs high-energy photons and a bottom cell that absorbs low-energy photons. Such a device can be fabricated as a stack of layers, with the top and bottom cell interconnected to each other. Monolithic integration of a perovskite solar cell and silicon solar cell into a tandem device is a promising...
• Winning a Nobel Prize may be bad for your productivity AI翻译
  作者：Shultz, David
• Translation dynamics in human cells visualized at high resolution reveal cancer drug action AI翻译
  作者：Xing, Huaipeng; Taniguchi, Reiya; Khusainov, Iskander; Kreysing, Jan Philipp; Welsch, Sonja; Turonova, Beata; Beck, Martin
  作者单位：Max Planck Society; Goethe University Frankfurt; Max Planck Society; Goethe University Frankfurt
  摘要：Ribosomes catalyze protein synthesis by cycling through various functional states. These states have been extensively characterized in vitro, but their distribution in actively translating human cells remains elusive. We used a cryo-electron tomography-based approach and resolved ribosome structures inside human cells with high resolution. These structures revealed the distribution of functional states of the elongation cycle, a Z transfer RNA binding site, and the dynamics of ribosome expansi...
• Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing AI翻译
  作者：Liu, Shiheng; Wang, Hong; Li, Xiaorun; Zhang, Fan; Lee, Jane K. J.; Li, Zihang; Yu, Clinton; Hu, Jason J.; Zhao, Xiaojing; Suematsu, Takuma; Alvarez-Cabrera, Ana L.; Liu, Qiushi; Zhang, Liye; Huang, Lan; Aphasizheva, Inna; Aphasizhev, Ruslan; Zhou, Z. Hong
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Boston University; ShanghaiTech University; University of California System; University of California Irvine; Boston University
  摘要：In Trypanosoma brucei, the editosome, composed of RNA-editing substrate-binding complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA (gRNA)-programmed editing to recode cryptic mitochondrial transcripts into messenger RNAs (mRNAs). The mechanism of information transfer from gRNA to mRNA is unclear owing to a lack of high-resolution structures for these complexes. With cryo-electron microscopy and functional studies, we have captured gRNA-stabilizing RESC-A and gRNA-m...
• Succinct discoveries that inspire AI翻译
  作者：[Anonymous]