作者：Buckley, Yvonne M.; Torsney, Andrew
作者单位：Trinity College Dublin; Trinity College Dublin
摘要：Native and introduced megaherbivores similarly affect plant diversity and abundance
作者：Lundgren, Erick J.; Bergman, Juraj; Trepel, Jonas; le Roux, Elizabeth; Monsarrat, Sophie; Kristensen, Jeppe Aagaard; Pedersen, Rasmus Ostergaard; Pereyra, Patricio; Tietje, Melanie; Svenning, Jens-Christian
作者单位：Aarhus University; Aarhus University; Aarhus University; Queensland University of Technology (QUT); University of Gottingen; University of Pretoria; Aarhus University; University of Oxford; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
摘要：Large mammalian herbivores (megafauna) have experienced extinctions and declines since prehistory. Introduced megafauna have partly counteracted these losses yet are thought to have unusually negative effects on plants compared with native megafauna. Using a meta-analysis of 3995 plot-scale plant abundance and diversity responses from 221 studies, we found no evidence that megafauna impacts were shaped by nativeness, invasiveness, feralness, coevolutionary history, or functional and phylogenet...
作者：Montoya, Skye; Bourcier, Jessie; Noviski, Mark; Lu, Hao; Thompson, Meghan C.; Chirino, Alexandra; Jahn, Jacob; Sondhi, Anya K.; Gajewski, Stefan; Tan, Ying Siow (May); Yung, Stephanie; Urban, Aleksandra; Wang, Eric; Han, Cuijuan; Mi, Xiaoli; Kim, Won Jun; Sievers, Quinlan; Auger, Paul; Bousquet, Hugo; Brathaban, Nivetha; Bravo, Brandon; Gessner, Melissa; Guiducci, Cristiana; Iuliano, James N.; Kane, Tim; Mukerji, Ratul; Reddy, Panga Jaipal; Powers, Janine; de los Rios, Mateo Sanchez Garcia; Ye, Jordan; Risso, Carla Barrientos; Tsai, Daniel; Pardo, Gabriel; Notti, Ryan Q.; Pardo, Alejandro; Affer, Maurizio; Nawaratne, Vindhya; Totiger, Tulasigeri M.; Pena-Velasquez, Camila; Rhodes, Joanna M.; Zelenetz, Andrew D.; Alencar, Alvaro; Roeker, Lindsey E.; Mehta, Sanjoy; Garippa, Ralph; Linley, Adam; Soni, Rajesh Kumar; Skanland, Sigrid S.; Brown, Robert J.; Mato, Anthony R.; Hansen, Gwenn M.; Abdel-Wahab, Omar; Taylor, Justin
作者单位：University of Miami; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Oslo; University of Oslo; Jackson Laboratory; Rockefeller University; Northwell Health; Memorial Sloan Kettering Cancer Center; University of Liverpool; Columbia University
摘要：Increasing use of covalent and noncovalent inhibitors of Bruton's tyrosine kinase (BTK) has elucidated a series of acquired drug-resistant BTK mutations in patients with B cell malignancies. Here we identify inhibitor resistance mutations in BTK with distinct enzymatic activities, including some that impair BTK enzymatic activity while imparting novel protein-protein interactions that sustain B cell receptor (BCR) signaling. Furthermore, we describe a clinical-stage BTK and IKZF1/3 degrader, N...
作者：Sloin, Hadas E.; Spivak, Lidor; Levi, Amir; Gattegno, Roni; Someck, Shirly; Stark, Eran
作者单位：Tel Aviv University; Tel Aviv University; University of Haifa; University of Oxford
摘要：Hippocampal theta-phase precession is involved in spatiotemporal coding and in generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than one-third of the CA1 artificial fields exhibited synthetic precessio...
