Local activation of CA1 pyramidal cells induces theta-phase precession

• 成果类型: Article
• 署名作者: Sloin, Hadas E.; Spivak, Lidor; Levi, Amir; Gattegno, Roni; Someck, Shirly; Stark, Eran
• 署名单位: Tel Aviv University; Tel Aviv University; University of Haifa; University of Oxford
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9220
• DOI: 10.1126/science.adk2456
• 发表日期: 2024-02-02
• 页码: 551-558
• 关键词: hippocampal place cells; medial entorhinal cortex; gamma oscillations; SEQUENCES; neurons; DYNAMICS; MODEL; CODE; computation; populations

摘要

Hippocampal theta-phase precession is involved in spatiotemporal coding and in generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than one-third of the CA1 artificial fields exhibited synthetic precession that persisted for a full theta cycle. By contrast, artificial fields in the parietal cortex did not exhibit synthetic precession. These findings are incompatible with precession models based on inheritance, dual-input, spreading activation, inhibition-excitation summation, or somato-dendritic competition. Thus, a precession generator resides locally within CA1.