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作者：Li, Fang; Zhu, W. Felix; Empel, Claire; Datsenko, Oleksandr; Kumar, Adarsh; Xu, Yameng; Ehrler, Johanna H. M.; Atodiresei, Iuliana; Knapp, Stefan; Mykhailiuk, Pavel K.; Proschak, Ewgenij; Koenigs, Rene M.
作者单位：RWTH Aachen University; Goethe University Frankfurt; Enamine Ltd; Goethe University Frankfurt; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv
摘要：The Pauson-Khand reaction has in the past 50 years become one of the most common cycloaddition reactions in chemistry. Coupling two unsaturated bonds with carbon monoxide, the transformation remains limited to CO as a C1 building block. Herein we report analogous cycloaddition reactions with nitrenes as an N1 unit. The reaction of a nonconjugated diene with a nitrene precursor produces bicyclic bioisosteres of common saturated heterocycles such as piperidine, morpholine, and piperazine. Experi...
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作者：Liu, Zi-Xian; Zhang, Shouyue; Zhu, Han-Zhou; Chen, Zhi-Hang; Yang, Yun; Li, Long-Qi; Lei, Yuan; Liu, Yun; Li, Dan-Yuan; Sun, Ao; Li, Cheng-Ping; Tan, Shun-Qing; Wang, Gao-Li; Shen, Jie-Yi; Jin, Shuai; Gao, Caixia; Liu, Jun-Jie Gogo
作者单位：Tsinghua University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Ribozymes are catalytic RNAs with diverse functions including self-splicing and polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and sequence-specific DNA endonucleases, which could be repurposed as DNA manipulation tools. Focused on bacterial group II-C introns, we found that many systems without intron-encoded protein propagate multiple copies in their resident genomes. These introns, named HYdrolytic Endonucleolytic Ribozymes (HYERs), cleaved RNA, singl...
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作者：Voosen, Paul
摘要：On a remote Pacific island, clues to El Nino's future are preserved in ancient reefs
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作者：McAllister, Haley P.; Kalow, Julia A.
作者单位：Northwestern University
摘要：Multiple properties can be programmed into a single dynamic material by using heat
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作者：Brainard, Jeffrey
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作者：Girkin, Nicholas T.; Davidson, Scott J.
作者单位：University of Nottingham; University of Plymouth
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作者：[Anonymous]
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作者：Frappier, Melanie
摘要：A physicist's wild romp through the multiverse probes space-time, string theory, and everything in between
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作者：Boynton, Nicholas R.; Dennis, Joseph M.; Dolinski, Neil D.; Lindberg, Charlie A.; Kotula, Anthony P.; Grocke, Garrett L.; Vivod, Stephanie L.; Lenhart, Joseph L.; Patel, Shrayesh N.; Rowan, Stuart J.
作者单位：University of Chicago; National Institute of Standards & Technology (NIST) - USA; National Aeronautics & Space Administration (NASA); NASA Glenn Research Center; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago
摘要：Pluripotency, which is defined as a system not fixed as to its developmental potentialities, is typically associated with biology and stem cells. Inspired by this concept, we report synthetic polymers that act as a single pluripotent feedstock and can be differentiated into a range of materials that exhibit different mechanical properties, from hard and brittle to soft and extensible. To achieve this, we have exploited dynamic covalent networks that contain labile, dynamic thia-Michael bonds, ...
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作者：Ray, Victor
作者单位：University of Iowa; University of Iowa; Harvard University
摘要：A more inclusive society begins with imagining audacious alternatives to today's systems, argues a sociologist
