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作者：Travisano, Michael
作者单位：University of Minnesota System; University of Minnesota Twin Cities
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作者：Casirati, Gabriele
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：The discovery that our immune system not only provides constant surveillance against the development of neoplastic disorders but may also be artificially reprogrammed to recognize and eradicate established malignancies has transformed our perspective on oncology treatment and prognosis. The exploitation of monoclonal antibodies (mAbs) has paved the road to antigendirected targeting of cancerous cells and led to the development of chimeric antigen receptor (CAR) T cells. This revolutionary cell...
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作者：Voosen, Paul
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作者：Parr, Catherine L.; te Beest, Mariska; Stevens, Nicola
作者单位：University of Liverpool; University of Pretoria; University of Witwatersrand; Utrecht University; Nelson Mandela University; National Research Foundation - South Africa; South African Environmental Observation Network (SAEON); University of Oxford
摘要：The Bonn Challenge was launched by the German government and the International Union for Conservation of Nature (IUCN) in 2011 with the goal of restoring 350 million ha of degraded and deforested landscapes by 2030. Although there is acknowledgment that forest landscape restoration (FLR) promoting tree planting should not cause the loss or conversion of open, nonforested ecosystems (i.e., they should not be afforested) (1), concerns have been raised that the focus on tree-based restoration com...
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作者：Thorp, H. Holden
摘要：On the television program MythBusters, which aired on the Discovery Channel from 2003 to 2016, the hosts Adam Savage and Jamie Hyneman tested popular myths and ideas arising everywhere from folklore to popular culture, designating them as either busted or confirmed. The show used engaging and entertaining variations on the scientific method to answer questions such as whether you get wetter when walking or running in the rain or what the fastest way is to board an airplane. I hear frequently f...
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作者：Kinzig, Charles G.; Zakusilo, George; Takai, Kaori K.; Myler, Logan R.; de Lange, Titia
作者单位：Rockefeller University; Cornell University; Weill Cornell Medicine
摘要：Telomerase, the enzyme that maintains telomeres at natural chromosome ends, should be repressed at double-strand breaks (DSBs), where neotelomere formation can cause terminal truncations. We developed an assay to detect neotelomere formation at Cas9- or I-SceI-induced DSBs in human cells. Telomerase added telomeric repeats to DSBs, leading to interstitial telomeric repeat insertions or the formation of functional neotelomeres accompanied by terminal deletions. The threat that telomerase poses ...
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作者：Thynne, Elisha; Kobe, Bostjan
作者单位：University of Kiel; Max Planck Society; University of Queensland
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作者：McCarthy, Patrick; Kirshner, Robert P.; Shelton, Robert N.
作者单位：National Science Foundation (NSF)
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作者：Roeer, Jan Philipp
摘要：Oh, now I get it, my colleague said. That's why you put so much effort into your exams. Over lunch with a fellow faculty member, I had been sharing the struggles I experienced years ago as a student with exam anxiety. Her comment surprised me a bit. But it got me thinking about why, since starting out as a professor 7 years ago, I have prioritized easing my students' nervousness before exams. I realized she probably had a point: My experiences as a student helped me understand what I could do ...
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作者：Han, Guopeng; Vasylenko, Andrij; Daniels, Luke M.; Collins, Chris M.; Corti, Lucia; Chen, Ruiyong; Niu, Hongjun; Manning, Troy D.; Antypov, Dmytro; Dyer, Matthew S.; Lim, Jungwoo; Zanella, Marco; Sonni, Manel; Bahri, Mounib; Jo, Hongil; Dang, Yun; Robertson, Craig M.; Blanc, Frederic; Hardwick, Laurence J.; Browning, Nigel D.; Claridge, John B.; Rosseinsky, Matthew J.
作者单位：University of Liverpool; University of Liverpool; University of Liverpool; University of Liverpool; University of Liverpool
摘要：Fast cation transport in solids underpins energy storage. Materials design has focused on structures that can define transport pathways with minimal cation coordination change, restricting attention to a small part of chemical space. Motivated by the greater structural diversity of binary intermetallics than that of the metallic elements, we used two anions to build a pathway for three-dimensional superionic lithium ion conductivity that exploits multiple cation coordination environments. Li7S...
