6684期

最新文章

• A river in flux AI翻译
  作者：Grossman, Daniel
  摘要：Extreme flooding and droughts may be the new norm for the Amazon, challenging its people and ecosystems
• Ethical treatment of Iran's research animals AI翻译
  作者：Mostafavinia, Atarodsadat; Ghoreishi, Seyed K.
  作者单位：Islamic Azad University; University of Qom
• The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity AI翻译
  作者：Sharma, Pankaj; Zhang, Xiaolong; Ly, Kevin; Zhang, Yuxiang; Hu, Yu; Ye, Adam Yongxin; Hu, Jianqiao; Kim, Ji Hyung; Lou, Mumeng; Wang, Chong; Celuzza, Quinton; Kondo, Yuji; Furukawa, Keiko; Bundle, David R.; Furukawa, Koichi; Alt, Frederick W.; Winau, Florian
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Howard Hughes Medical Institute; Harvard Medical School; Nagoya University; Chubu University; University of Alberta; Korea University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：INTRODUCTION Viral infections, such as influenza, impose a substantial burden on public health. In the absence of potent antiviral drugs, vaccination is the best strategy to control infectious disease. The goal of efficient vaccines is the induction of an immune response that is characterized by production of antibodies of high affinity and broad reactivity. The diversity of antibodies is especially important to facilitate cross-protective immunity in response to mutating viral strains. Antibo...
• Accelerated photochemical reactions at oil-water interface exploiting melting point depression AI翻译
  作者：Tian, Ya-Ming; Silva, Wagner; Gschwind, Ruth M.; Koenig, Burkhard
  作者单位：University of Regensburg
  摘要：Water can accelerate a variety of organic reactions far beyond the rates observed in classical organic solvents. However, using pure water as a solvent introduces solubility constraints that have limited the applicability of efficient photochemistry in particular. We report here the formation of aggregates between pairs of arenes, heteroarenes, enamines, or esters with different electron affinities in an aqueous medium, leading to an oil-water phase boundary through substrate melting point dep...
• An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance AI翻译
  作者：Wu, Kelvin J. Y.; Tresco, Ben I. C.; Ramkissoon, Antonio; Aleksandrova, Elena V.; Syroegin, Egor A.; See, Dominic N. Y.; Liow, Priscilla; Dittemore, Georgia A.; Yu, Meiyi; Testolin, Giambattista; Mitcheltree, Matthew J.; Liu, Richard Y.; Svetlov, Maxim S.; Polikanov, Yury S.; Myers, Andrew G.
  作者单位：Harvard University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Merck & Company; Merck & Company USA
  摘要：We report the design conception, chemical synthesis, and microbiological evaluation of the bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse forms of antimicrobial resistance that render modern antibiotics ineffective. CRM exhibits in vitro and in vivo efficacy against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. We show that CRM is highly preo...
• Paired plant immune CHS3-CSA1 receptor alleles form distinct hetero-oligomeric complexes AI翻译
  作者：Yang, Yu; Furzer, Oliver J.; Fensterle, Eleanor P.; Lin, Shu; Zheng, Zhiyu; Kim, Nak Hyun; Wan, Li; Dangl, Jeffery L.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Howard Hughes Medical Institute; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
  摘要：Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) analyzed to date oligomerize and form resistosomes upon activation to initiate immune responses. Some NLRs are encoded in tightly linked co-regulated head-to-head genes whose products function together as pairs. We uncover the oligomerization requirements for different Arabidopsis paired CHS3-CSA1 alleles. These pairs form resting-state heterodimers that oligomerize into complexes distinct from NLRs analyzed previously...
• The end of the auk AI翻译
  作者：Barrow Jr, Mark V.
  作者单位：Virginia Polytechnic Institute & State University
  摘要：An anthropologist recounts how a pair of 19th-century naturalists traced an elusive bird's extinction in real time
• Early hunters used stone wall? AI翻译
  作者：Brainard, Jeffrey
• China reduces suicides by cutting air pollution AI翻译
  作者：Brainard, Jeffrey
• Diet explains Serengeti grazers' predictable migration AI翻译
  作者：Pennisi, Elizabeth