6688期

最新文章

• Training future space explorers AI翻译
  作者：Akhavan-Tafti, Mojtaba
  作者单位：University of Michigan System; University of Michigan
• Reverse EU's growing greenlash AI翻译
  作者：Chapron, Guillaume
  作者单位：Swedish University of Agricultural Sciences
  摘要：After several weeks of violent protests, European farmers have achieved a tactical triumph that does not bode well for the future of environmental policies. In response to the demonstrations, the European Commission has enacted a derogation in the European Union's (EU's) Common Agricultural Policy (CAP) to set aside 4% of farmland for biodiversity and landscape protection, withdrawn a bill to halve pesticide use, removed a target to reduce agriculture emissions by 30% by 2040, and called for f...
• Dispersal stabilizes coupled ecological and evolutionary dynamics in a host-parasitoid system AI翻译
  作者：Nell, Lucas A.; Kishinevsky, Miriam; Bosch, Michael J.; Sinclair, Calvin; Bhat, Karuna; Ernst, Nathan; Boulaleh, Hamze; Oliver, Kerry M.; Ives, Anthony R.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University System of Georgia; University of Georgia; Stanford University; United States Department of Agriculture (USDA)
  摘要：When ecological and evolutionary dynamics occur on comparable timescales, persistence of the ensuing eco-evolutionary dynamics requires both ecological and evolutionary stability. This unites key questions in ecology and evolution: How do species coexist, and what maintains genetic variation in a population? In this work, we investigated a host-parasitoid system in which pea aphid hosts rapidly evolve resistance to Aphidius ervi parasitoids. Field data and mathematical simulations showed that ...
• Flowering plants brought doom and boom for ants AI翻译
  作者：Brainard, Jeffrey
• Fork coupling directs DNA replication elongation and termination AI翻译
  作者：Liu, Yang; Zhangding, Zhengrong; Liu, Xuhao; Gan, Tingting; Ai, Chen; Wu, Jinchun; Liang, Haoxin; Chen, Mohan; Guo, Yuefeng; Lu, Rusen; Jiang, Yongpeng; Ji, Xiong; Gao, Ning; Kong, Daochun; Li, Qing; Hu, Jiazhi
  作者单位：Peking University; Peking University; Peking University; Peking University; Peking University
  摘要：DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To investigate the coordination of replication forks, we developed a replication-associated in situ HiC method to capture chromatin interactions involving nascent DNA. We identify more than 2000 fountain-like structures of chromatin contacts in human and mouse genomes, ind...
• Virus challenge tests launched AI翻译
  作者：Brainard, Jeffrey
• Science, left and right AI翻译
  作者：Brainard, Jeffrey
• Continuous evolution of compact protein degradation tags regulated by selective molecular glues AI翻译
  作者：Mercer, Jaron A. M.; Decarlo, Stephan J.; Burman, Shourya S. Roy; Sreekanth, Vedagopuram; Nelson, Andrew T.; Hunkeler, Moritz; Chen, Peter J.; Donovan, Katherine A.; Kokkonda, Praveen; Tiwari, Praveen K.; Shoba, Veronika M.; Deb, Arghya; Choudhary, Amit; Fischer, Eric S.; Liu, David R.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Conditional protein degradation tags (degrons) are usually >100 amino acids long or are triggered by small molecules with substantial off-target effects, thwarting their use as specific modulators of endogenous protein levels. We developed a phage-assisted continuous evolution platform for molecular glue complexes (MG-PACE) and evolved a 36-amino acid zinc finger (ZF) degron (SD40) that binds the ubiquitin ligase substrate receptor cereblon in complex with PT-179, an orthogonal thalidomide der...
• Is Arctic melt driving European heat waves? AI翻译
  作者：Kintisch, Eli
  摘要：Cold blob from increased meltwater alters key weather patterns, study suggests
• Two-dimensional materials by large-scale computations and chemical exfoliation of layered solids AI翻译
  作者：Bjoerk, Jonas; Zhou, Jie; Persson, Per O. a.; Rosen, Johanna
  作者单位：Linkoping University; Linkoping University; Linkoping University
  摘要：MXenes are a family of two-dimensional (2D) materials typically formed by etching the A element from a parent MAX phase. Computational screening for other 3D precursors suitable for such exfoliation is challenging because of the intricate chemical processes involved. We present a theoretical approach for predicting 2D materials formed through chemical exfoliation under acidic conditions by identifying 3D materials amenable for selective etching. From a dataset of 66,643 3D materials, we identi...