6688期

最新文章

• Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus AI翻译
  作者：Cross, Robert W.; Woolsey, Courtney; Chu, Victor C.; Babusis, Darius; Bannister, Roy; Vermillion, Meghan S.; Geleziunas, Romas; Barrett, Kimberly T.; Bunyan, Elaine; Nguyen, Anh-Quan; Cihlar, Tomas; Porter, Danielle P.; Prasad, Abhishek N.; Deer, Daniel J.; Borisevich, Viktoriya; Agans, Krystle N.; Martinez, Jasmine; Harrison, Mack B.; Dobias, Natalie S.; Fenton, Karla A.; Bilello, John P.; Geisbert, Thomas W.
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Gilead Sciences
  摘要：Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment. In this work, we show that ODV and its circulating parent nucleoside metabolite, GS-441524, have similar in vitro antiviral activity against filoviruses, including Marburg virus, Ebola virus, and Sudan virus (SUDV). We also report that once-daily oral ODV treatment of cynomolgus monkeys for 10 days beginning 24 hours after SUDV exp...
• Reinforcing self-assembly of hole transport molecules for stable inverted perovskite solar cells AI翻译
  作者：Tang, Hongcai; Shen, Zhichao; Shen, Yangzi; Yan, Ge; Wang, Yanbo; Han, Qifeng; Han, Liyuan
  作者单位：Shanghai Jiao Tong University
  摘要：Power conversion efficiencies (PCEs) of inverted perovskite solar cells (PSCs) have been improved by the use of a self-assembled monolayer (SAM) hole transport layer. Long-term stability of PSCs requires keeping the SAM compact under the perovskite layer during operation. We found that strong polar solvents in the perovskite precursor desorb the SAM if it is anchored on substrates by hydrogen-bonded, rather than covalently bonded, hydroxyl groups. We used atomic-layer deposition to create an i...
• Men recall fewer women stars AI翻译
  作者：Brainard, Jeffrey
• Seafloor fiber-optic cables become sensor stations AI翻译
  作者：Voosen, Paul
  摘要：Smart cables will detect earthquakes, tsunamis, and global warming
• Aminative Suzuki-Miyaura coupling (vol 383, pg 1019, 2024) AI翻译
  作者：[Anonymous]
• The DTC microbiome testing industry needs more regulation AI翻译
  作者：Hoffmann, Diane E.; von Rosenvinge, Erik C.; Roghmann, Mary-Claire; Palumbo, Francis B.; Mcdonald, Daniel; Ravel, Jacques
  作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University of California System; University of California San Diego; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
  摘要：A growing body of research has suggested the potential for improving human health by better understanding the human microbiome. This research has led to the emergence of a global industry selling direct-to-consumer (DTC) microbiome testing services. Regulation of this industry has been generally ignored despite its having made a mark on the lifestyle health and wellness market. Yet companies' claims of having the ability to detect abnormal microbiomes are not substantiated by research; the tes...
• Efforts to screen kids for type 1 diabetes multiply AI翻译
  作者：Couzin-Frankel, Jennifer
  摘要：Blood tests can detect the disease process early, avoiding complications and aiding treatment
• Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans AI翻译
  作者：Morais, Sarah; Winkler, Sarah; Zorea, Alvah; Levin, Liron; Nagies, Falk S. P.; Kapust, Nils; Lamed, Eva; Artan-Furman, Avital; Bolam, David N.; Yadav, Madhav P.; Bayer, Edward A.; Martin, William F.; Mizrahi, Itzhak
  作者单位：Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Heinrich Heine University Dusseldorf; Weizmann Institute of Science; Newcastle University - UK; United States Department of Agriculture (USDA)
  摘要：INTRODUCTION Mammals, including humans, rely on their gut's microbial community to break down plant cell wall components, notably cellulose and associated polysaccharides. However, there is limited evidence for cellulose fermentation in the human gut despite the benefits of cellulose-containing dietary fiber for gut-microbiome health and overall human well-being. RATIONALE By investigating the presence of heretofore undescribed bacterial species within the human-gut microbiota that degrade com...
• 'Damning' FDA inspection report undermines Alzheimer's drug AI翻译
  作者：Piller, Charles
  摘要：Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences
• An oral antiviral for Ebola disease AI翻译
  作者：Sprecher, Armand; Van Herp, Michel
  作者单位：Doctors Without Borders
  摘要：Marburg disease and Ebola disease-which includes Ebola virus disease (EVD) and Sudan virus disease (SVD)-are collectively called filovirus diseases (FVDs). These cause considerable mortality. During outbreaks, when a case of FVD is identified, their close contacts receive a daily visit from follow-up teams for 21 days, which is the extent of the incubation period. If a contact becomes ill, they are brought to a treatment unit, where they remain if they have FVD. This procedure should minimize ...