作者：Shen, Changyu; Liu, Xianhu
作者单位：Zhengzhou University
作者：Rasmussen, Martin Kaag; Mollgard, Kjeld; Bork, Peter A. R.; Weikop, Pia; Esmail, Tina; Drici, Lylia; Albrechtsen, Nicolai J. Wewer; Carlsen, Jonathan Frederik; Huynh, Nguyen P. T.; Ghitani, Nima; Mann, Matthias; Goldman, Steven A.; Mori, Yuki; Chesler, Alexander T.; Nedergaard, Maiken
作者单位：University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of Rochester; Max Planck Society; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
摘要：Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, similar to 11% of the CSF proteome is altered, with up...
作者：Needham, Brittany
作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
作者：Rosenberg, Steven A.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
作者：Russo, Andrew F.; Iliff, Jeffrey J.
作者单位：University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System; US Department of Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound Health Care System; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Migraine pain is believed to result from the activation of pain receptors (nociceptors) after the cortical spreading depression (CSD) that is associated with the aura phase of migraine ( 1 ). Previous studies have demonstrated that preclinical CSD events release small molecules through the cerebrospinal fluid (CSF) that activate and sensitize afferent trigeminal fibers within the meninges ( 2 , 3 ). However, it has been thought that trigeminal ganglia reside outside the blood-brain barrier and...
作者：Oguchi, Akiko; Suzuki, Akari; Komatsu, Shuichiro; Yoshitomi, Hiroyuki; Bhagat, Shruti; Son, Raku; Bonnal, Raoul Jean Pierre; Kojima, Shohei; Koido, Masaru; Takeuchi, Kazuhiro; Myouzen, Keiko; Inoue, Gyo; Hirai, Tomoya; Sano, Hiromi; Takegami, Yujiro; Kanemaru, Ai; Yamaguchi, Itaru; Ishikawa, Yuki; Tanaka, Nao; Hirabayashi, Shigeki; Konishi, Riyo; Sekito, Sho; Inoue, Takahiro; Kere, Juha; Takeda, Shunichi; Takaori-Kondo, Akifumi; Endo, Itaru; Kawaoka, Shinpei; Kawaji, Hideya; Ishigaki, Kazuyoshi; Ueno, Hideki; Hayashizaki, Yoshihide; Pagani, Massimiliano; Carninci, Piero; Yanagita, Motoko; Parrish, Nicholas; Terao, Chikashi; Yamamoto, Kazuhiko; Murakawa, Yasuhiro
作者单位：RIKEN; Kyoto University; Kyoto University; RIKEN; IFOM - FIRC Institute of Molecular Oncology; Kyoto University; RIKEN; University of Tokyo; University of Tokyo; RIKEN; Kyoto University; Yokohama City University; Kyoto University; Kyushu University; Kyoto University; Mie University; Karolinska Institutet; University of Helsinki; Folkhalsan Research Center; Kyoto University; Shenzhen University; Tohoku University; Tokyo Metropolitan Institute of Medical Science; RIKEN; RIKEN; RIKEN; RIKEN; Human Technopole; Shizuoka General Hospital; University of Shizuoka
摘要：INTRODUCTION: Enhancers are distal cis-regulatory elements that increase the expression of target genes. Active enhancers produce bidirectional enhancer RNAs (eRNAs). Transcription of eRNAs can be used to measure enhancer activity and to delineate enhancer architecture at nucleotide resolution. Profiling of transcribed enhancers in single human cells can provide insights into cell type-specific gene regulation and genetic predisposition to diseases. However, comprehensive maps of eRNAs in cell...
