6705期

最新文章

• Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years AI翻译
  作者：Li, Liming; Comi, Troy J.; Bierman, Rob F.; Akey, Joshua M.
  作者单位：Southeast University - China; Princeton University
  摘要：Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods to estimate the amount of human-introgressed sequences in Neanderthals and apply it to whole-genome sequence data from 2000 modern humans and three Neanderthals. We estimate that Neanderthals have 2.5 to 3.7% human ancestry, and we leverage human-introgressed sequences in Neanderthals to revise estimates of Neande...
• Can 'cow flu' be eliminated-or is it too late? AI翻译
  作者：Cohen, Jon
• Stop H5N1 influenza in US cattle now AI翻译
  作者：Lewis, Nicola; Beer, Martin
  作者单位：Francis Crick Institute; Friedrich Loeffler Institute
  摘要：The relentless march of a highly pathogenic avian influenza virus (HPAIV) strain, known as H5N1, to become an unprecedented panzootic continues unchecked. The leap of H5N1 clade 2.3.4.4b from Eurasia and Africa to North America in 2021 and its further spread to South America and the Antarctic have exposed new avian and mammalian populations to the virus and led to outbreaks on an unrivaled scale. The virus has infected wild birds across vast geographic regions and caused wildlife deaths in som...
• The Response AI翻译
  作者：Black, Amanda; Tylianakis, Jason M.
  作者单位：Lincoln University - New Zealand; University of Canterbury
• Structured electrons with chiral mass and charge AI翻译
  作者：Fang, Yiqi; Kuttruff, Joel; Nabben, David; Baum, Peter
  作者单位：University of Konstanz
  摘要：Chirality is a phenomenon with widespread relevance in fundamental physics, material science, chemistry, optics, and spectroscopy. In this work, we show that a free electron can be converted by the field cycles of laser light into a right-handed or left-handed coil of mass and charge. In contrast to phase-vortex beams, our electrons maintained a flat de Broglie wave but obtained their chirality from the shape of their expectation value in space and time. Measurements of wave function densities...
• Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity AI翻译
  作者：Wu, Meng-Ju; Kondo, Hiroshi; Kammula, Ashwin V.; Shi, Lei; Xiao, Yi; Dhiab, Sofiene; Xu, Qin; Slater, Chloe J.; Avila, Omar I.; Merritt, Joshua; Kato, Hiroyuki; Kattel, Prabhat; Sussman, Jonathan; Gritti, Ilaria; Eccleston, Jason; Sun, Yi; Cho, Hyo Min; Olander, Kira; Katsuda, Takeshi; Shi, Diana D.; Savani, Milan R.; Smith, Bailey C.; Cleary, James M.; Mostoslavsky, Raul; Vijay, Vindhya; Kitagawa, Yosuke; Wakimoto, Hiroaki; Jenkins, Russell W.; Yates, Kathleen B.; Paik, Jihye; Tassinari, Ania; Saatcioglu, Duygu Hatice; Tron, Adriana E.; Haas, Wilhelm; Cahill, Daniel; Mcbrayer, Samuel K.; Manguso, Robert T.; Bardeesy, Nabeel
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Universite Paris Saclay; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Cornell University; Weill Cornell Medicine; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores antitumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. IDH1-mutant solid tumors show selective hypermeth...
• Stunning 3D chromosomes preserved in thawed mammoths AI翻译
  作者：Stone, Richard
• On Call: A Doctor's Journey in Public Service AI翻译
  作者：Thompson, Valerie
  作者单位：George Washington University
• World science and Indigenous knowledge AI翻译
  作者：Ahdar, Rex; Boyd, Brian; Chaudhuri, Ananish; Clements, Kendall D.; Cooper, Garth; Elliffe, Douglas; Gill, Brian; Gray, Russell D.; Hamilton-Hart, Natasha; Lillis, David; Matthews, Michael; Raine, John; Rata, Elizabeth; Schwerdtfeger, Peter
  作者单位：University of Auckland; University of Auckland; University of Auckland; University of Auckland; University of Auckland; University of New South Wales Sydney; Auckland University of Technology; University of Auckland; Massey University
• Biologist returns after harassment suspension AI翻译
  作者：Wadman, Meredith