作者：Coe, Hugh
作者单位：University of Manchester; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; University of Manchester
摘要：New atmospheric particles form when the stratosphere intrudes into the troposphere Aerosol particles smaller than 1 mm in diameter are ubiquitous in the troposphere, the lowest part of Earth's atmosphere responsible for weather and a major part of the climate system. They act as condensation sites for water vapor from which cloud droplets grow and hence, are part of the hydrological cycle. Precipitation removes these particles on timescales of a few days to weeks. A major challenge is understa...
作者：Coupland, Claire E.; Karimi, Ryan; Bueler, Stephanie A.; Liang, Yingke; Courbon, Gautier M.; Di Trani, Justin M.; Wong, Cassandra J.; Saghian, Rayan; Youn, Ji-Young; Wang, Lu-Yang; Rubinstein, John L.
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto
摘要：Intercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic neuron, the proton pumping vesicular- or vacuolar-type ATPase (V-ATPase) powers neurotransmitter loading into synaptic vesicles (SVs), with the V(1 )complex dissociating from the membrane region of the enzyme before exocytosis. We isolated SVs from rat brain using SidK, a V-ATPase-binding bacterial effector protein. Single-particle electr...
作者：Isidoro-Ayza, Marcos; Klein, Bruce S.
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：Millions of hibernating bats across North America have died from white-nose syndrome (WNS), an emerging disease caused by a psychrophilic (cold-loving) fungus, Pseudogymnoascus destructans, that invades their skin. Mechanisms of P. destructans invasion of bat epidermis remain obscure. Guided by our in vivo observations, we modeled hibernation with a newly generated little brown bat (Myotis lucifugus) keratinocyte cell line. We uncovered the stealth intracellular lifestyle of P. destructans, wh...
作者：Matzke, Nicholas J.
作者单位：University of Auckland
