6707期

最新文章

• Prime stegosaur skeleton sold for record sum AI翻译
  作者：Brainard, Jeffrey
• First, the vultures died. Then, the humans AI翻译
  作者：Brainard, Jeffrey
• GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans AI翻译
  作者：Kim, Kyu Sik; Park, Joon Seok; Hwang, Eunsang; Park, Min Jung; Shin, Hwa Yun; Lee, Young Hee; Kim, Kyung Min; Gautron, Laurent; Godschall, Elizabeth; Portillo, Bryan; Grose, Kyle; Jung, Sang-Ho; Baek, So Lin; Yun, Young Hyun; Lee, Doyeon; Kim, Eunseong; Ajwani, Jason; Yoo, Seong Ho; Gueler, Ali D.; Williams, Kevin W.; Choi, Hyung Jin
  作者单位：Seoul National University (SNU); University of Texas System; University of Texas Southwestern Medical Center; Seoul National University (SNU); University of Virginia; Seoul National University (SNU); University of London; University College London; Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU)
  摘要：Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMHGLP-1R neurons caused ...
• A mega-electron volt emission line in the spectrum of a gamma-ray burst AI翻译
  作者：Ravasio, Maria Edvige; Salafia, Om Sharan; Oganesyan, Gor; Mei, Alessio; Ghirlanda, Giancarlo; Ascenzi, Stefano; Banerjee, Biswajit; Macera, Samanta; Branchesi, Marica; Jonker, Peter G.; Levan, Andrew J.; Malesani, Daniele B.; Mulrey, Katharine B.; Giuliani, Andrea; Celotti, Annalisa; Ghisellini, Gabriele
  作者单位：Radboud University Nijmegen; Istituto Nazionale Astrofisica (INAF); Gran Sasso Science Institute (GSSI); Gran Sasso Science Institute (GSSI); Istituto Nazionale di Fisica Nucleare (INFN); Autonomous University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencias del Espacio (ICE); Institut d'Estudis Espacials de Catalunya (IEEC); University of Warwick; University of Copenhagen; Niels Bohr Institute; Istituto Nazionale Astrofisica (INAF); International School for Advanced Studies (SISSA)
  摘要：A long gamma-ray burst (GRB) is observed when the collapse of a massive star produces an ultrarelativistic outflow pointed toward Earth. Gamma-ray spectra of long GRBs are smooth, typically modeled by joint power-law segments describing a continuum, with no detected spectral lines. We report a significant (>6 sigma) narrow emission feature at similar to 10 mega-electron volts (MeV) in the spectrum of the bright GRB 221009A. Over 80 seconds, it evolves in energy (similar to 12 to similar to 6 M...
• Cultural constructs of the body AI翻译
  作者：Camporesi, Silvia
  作者单位：KU Leuven
  摘要：Protective sports policies ostensibly based on biology inform broader ideas about ability and identity
• Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress AI翻译
  作者：Condic, Natalia; Amiji, Hatim; Patel, Dipak; Shropshire, William Charles; Lermi, Nejla Ozirmak; Sabha, Youssef; John, Beryl; Hanson, Blake; Karras, Georgios Ioannis
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; UTMD Anderson Cancer Center
  摘要：Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of b...
• US back in the race to forge unknown elements AI翻译
  作者：Service, Robert F.
  摘要：Atoms of element 116 show path to create element 120 and extend the periodic table
• Disability and disaster: A deadly duo AI翻译
  作者：Romanchuk, Kathryn; Rizzo, John-Ross
  作者单位：NYU Langone Medical Center; New York University; NYU Langone Medical Center
• Left in the dust AI翻译
  作者：Gonzalez, Roberto
  摘要：Communities living near mine wastes breathe air laden with potentially toxic dust. Health effects are now emerging
• Harnessing science, policy, and law to deliver clean air AI翻译
  作者：Lewis, Alastair; Misonne, Delphine; Scotford, Eloise
  作者单位：University of York - UK; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; University of Leeds; University of London; University College London
  摘要：Despite increasing evidence and awareness, many countries continue to have weak air quality regimes