Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress

• 成果类型: Article
• 署名作者: Condic, Natalia; Amiji, Hatim; Patel, Dipak; Shropshire, William Charles; Lermi, Nejla Ozirmak; Sabha, Youssef; John, Beryl; Hanson, Blake; Karras, Georgios Ioannis
• 署名单位: University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; UTMD Anderson Cancer Center
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12211
• DOI: 10.1126/science.adi3048
• 发表日期: 2024-07-26
• 关键词: copy number variation; saccharomyces-cerevisiae; maltotriose utilization; mal loci; EVOLUTION; canalization; capacitor; maltose; fermentation; trajectories

摘要

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.