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作者：Kawaoka, Jane; Lomvardas, Stavros
作者单位：Columbia University; Columbia University
摘要：Proper wiring of the nervous system depends on connections, or synapses, between specific neurons. This includes avoiding inappropriate interactions of a neuron with itself, a precision that is guided by cell surface proteins that act as barcodes to distinguish neuronal self from nonself (1). Although this concept is universal, the molecules that generate barcodes and the mechanisms that diversify them differ between organisms. In mammals, protocadherin proteins (Pcdh) are constituents of neur...
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作者：Dong, L. R.; Zhang, J.; Li, Y. Z.; Gao, Y. X.; Wang, M.; Huang, M. X.; Wang, J. S.; Chen, K. X.
作者单位：Beijing University of Technology; University of Hong Kong; University of Science & Technology Beijing
摘要：The inherent brittleness of ceramics, primarily due to restricted atomic motions from rigid ionic or covalent bonded structures, is a persistent challenge. This characteristic hinders dislocation nucleation in ceramics, thereby impeding the enhancement of plasticity through a dislocation-engineering strategy commonly used in metals. Finding a strategy that continuously generates dislocations within ceramics may enhance plasticity. Here, we propose a borrowing-dislocations strategy that uses a ...
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作者：Wang, Chien-An; John, Valentin; Tidjani, Hanifa; Yu, Cecile X.; Ivlev, Alexander S.; Deprez, Corentin; van Riggelen-Doelman, Floor; Woods, Benjamin D.; Hendrickx, Nico W.; Lawrie, William I. L.; Stehouwer, Lucas E. A.; Oosterhout, Stefan D.; Sammak, Amir; Friesen, Mark; Scappucci, Giordano; de Snoo, Sander L.; Rimbach-Russ, Maximilian; Borsoi, Francesco; Veldhorst, Menno
作者单位：Delft University of Technology; University of Wisconsin System; University of Wisconsin Madison
摘要：Qubits that can be efficiently controlled are essential for the development of scalable quantum hardware. Although resonant control is used to execute high-fidelity quantum gates, the scalability is challenged by the integration of high-frequency oscillating signals, qubit cross-talk, and heating. Here, we show that by engineering the hopping of spins between quantum dots with a site-dependent spin quantization axis, quantum control can be established with discrete signals. We demonstrate hopp...
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作者：Brainard, Jeffrey
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作者：Jain, Sanket
摘要：There's growing evidence that breathing polluted air increases the risk of osteoporosis
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作者：Kalantar-Zadeh, Kourosh; Daeneke, Torben; Tang, Junma
作者单位：University of Sydney; Royal Melbourne Institute of Technology (RMIT); University of New South Wales Sydney
摘要：Liquid metals may deliver greener and more sustainable chemical reactions
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作者：Thorp, H. Holden
摘要：The idea that universities in the United States-and especially their presidents-should be politically neutral was taking hold long before their recent struggles in responding to the Israel-Hamas war. A document called the Kalven Report that was produced at the University of Chicago in 1967 famously declared that the university is the home and sponsor of critics; it is not itself the critic. Thus, in matters of political controversy, the university best serves its faculty and students by remain...
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作者：Carder, Hayden M.; Occhialini, Gino; Bistoni, Giovanni; Riplinger, Christoph; Kwan, Eugene E.; Wendlandt, Alison E.
作者单位：Massachusetts Institute of Technology (MIT); University of Perugia; Merck & Company; Merck & Company USA
摘要：Stereochemical editing strategies have recently enabled the transformation of readily accessible substrates into rare and valuable products. Typically, site selectivity is achieved by minimizing kinetic complexity by using protecting groups to suppress reactivity at undesired sites (substrate control) or by using catalysts with tailored shapes to drive reactivity at the desired site (catalyst control). We propose network control, a contrasting paradigm that exploits hidden interactions between...
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作者：Li, Maolin; Yuan, Yujie; Harrison, Wesley; Zhang, Zhengyi; Zhao, Huimin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Enzymes capable of assimilating fluorinated feedstocks are scarce. This situation poses a challenge for the biosynthesis of fluorinated compounds used in pharmaceuticals, agrochemicals, and materials. We developed a photoenzymatic hydrofluoroalkylation that integrates fluorinated motifs into olefins. The photoinduced promiscuity of flavin-dependent ene-reductases enables the generation of carbon-centered radicals from iodinated fluoroalkanes, which are directed by the photoenzyme to engage ena...
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作者：Brainard, Jeffrey
