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作者:Gabriel, Alice-Agnes; Garagash, Dmitry I.; Palgunadi, Kadek H.; Mai, P. Martin
作者单位:University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Munich; Dalhousie University; King Abdullah University of Science & Technology; Institut Teknologi Sepuluh Nopember; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要:Earthquakes vary in size over many orders of magnitude, often rupturing in complex multifault and multievent sequences. Despite the large number of observed earthquakes, the scaling of the earthquake energy budget remains enigmatic. We propose that fundamentally different fracture processes govern small and large earthquakes. We combined seismological observations with physics-based earthquake models, finding that both dynamic weakening and restrengthening effects are non-negligible in the ene...
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作者:Mork, Daniel; Delaney, Scott; Dominici, Francesca
作者单位:Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
摘要:Air pollution causes premature death and disease and disproportionately harms non-white and lower-income groups in the United States. Government policies are responsible for the racial disparity in air pollution exposure and related health outcomes. Investigating complex relationships between policies, air pollution, and health requires (i) harmonized data connecting policies, environmental exposures, socioeconomic characteristics, and health at the individual and area level; (ii) interpretabl...
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作者:Kipnis, Jonathan
作者单位:Washington University (WUSTL)
摘要:Glymphatic-lymphatic brain cleansing may reveal new therapeutic strategies
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作者:Brainard, Jeffrey
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作者:Kiefer, Lea; Gaudin, Simon; Rajkumar, Sandy M.; Servito, Gabrielle Isabelle F.; Langen, Jennifer; Mui, Michael H.; Nawsheen, Shayra; Canzio, Daniele
作者单位:University of California System; University of California San Francisco; University of California System; University of California San Francisco; Ecole Normale Superieure de Lyon (ENS de LYON); University of California System; University of California San Francisco; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
摘要:Expression of Protocadherin (Pcdh) genes is critical to the generation of neuron identity and wiring of the nervous system. Pcdh alpha genes are arranged in clusters and exhibit a range of expression profiles, from stochastic to deterministic. Because Pcdh alpha promoters have high sequence identity and share distal enhancers, how distinct neurons choose which gene to express remains unclear. We show that the interplay between multiple enhancers, epigenetics, and genome folding orchestrates di...
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作者:Apte, Joshua S.; Manchanda, Chirag
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要:Variation in urban air pollution arises because of complex spatial, temporal, and chemical processes, which profoundly affect population exposure, human health, and environmental justice. This Review highlights insights from two popular in situ measurement methods-mobile monitoring and dense sensor networks-that have distinct but complementary strengths in characterizing the dynamics and impacts of the multidimensional urban air quality system. Mobile monitoring can measure many pollutants at ...
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作者:Morawska, Lidia; Li, Yuguo; Salthammer, Tunga
作者单位:Queensland University of Technology (QUT); University of Surrey; University of Hong Kong
摘要:The rapid global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the beginning of 2020 presented the world with its greatest health challenge in decades. It soon became clear that governments were unprepared to respond appropriately to this crisis. National and international public health authorities were confused about the transmission routes of the virus and the control measures required to protect against it. In particular, the need to reduce the risk of infection ...
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作者:Nieuwland, Ilja
作者单位:Royal Netherlands Academy of Arts & Sciences; Huygens Institute for the History of the Netherlands (KNAW)
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作者:Brainard, Jeffrey
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作者:Clery, Daniel
摘要:As private fleets grow, so do concerns about ozone-destroying effects of metal particles