6711期

最新文章

• Larger teams worsen brain drain AI翻译
  作者：Brainard, Jeffrey
• More than my gender AI翻译
  作者：Irrgeher, Johanna
  作者单位：University of Leoben
• Taking stock of global fisheries AI翻译
  作者：Froese, Rainer; Pauly, Daniel
  作者单位：Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; University of British Columbia
  摘要：Current stock assessment models overestimate productivity and recovery trajectory
• The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons AI翻译
  作者：Wernert, Florian; Moparthi, Satish Babu; Pelletier, Florence; Laine, Jeanne; Simons, Eline; Moulay, Gilles; Rueda, Fanny; Jullien, Nicolas; Benkhelifa-Ziyyat, Sofia; Papandreou, Marie-Jeanne; Leterrier, Christophe; Vassilopoulos, Stephane
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite
  摘要：Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin-coated structures and endocytosis along the axon initial segment (AIS) and their relationship to the periodic actin-spectrin scaffold that lines the axonal plasma membrane. A combination of super-resolution microscopy and platinum-replica electron microscopy on cultured neurons revealed that AIS ...
• Tribes to lead overdose studies AI翻译
  作者：Brainard, Jeffrey
• Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex AI翻译
  作者：Yang, Zhenlin; Mameri, Amel; Cattoglio, Claudia; Lachance, Catherine; Florez Ariza, Alfredo Jose; Luo, Jie; Humbert, Jonathan; Sudarshan, Deepthi; Banerjea, Arul; Galloy, Maxime; Fradet-Turcotte, Amelie; Lambert, Jean-Philippe; Ranish, Jeff A.; Cote, Jacques; Nogales, Eva
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; Laval University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Institute for Systems Biology (ISB); Laval University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The human nucleosome acetyltransferase of histone H4 (NuA4)/Tat-interactive protein, 60 kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucrose nonfermentable related 1 (SWR1) and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4, H2A, and H2A.Z to regulate gene expression and maintain genome stability. Our cryo-electron microscopy studies show that, within the NuA4/TIP60 complex, the E1A binding protein P400 (EP400) su...
• Disinformation resource closes AI翻译
  作者：Brainard, Jeffrey
• Sustainable polymers that stick inside and out AI翻译
  作者：Guan, Zhibin
  作者单位：University of California System; University of California Irvine
  摘要：A naturally occurring fatty acid yields a set of adhesives with different properties
• US agency funding for climate and health research falls short AI翻译
  作者：Wadman, Meredith
  摘要：Interdisciplinary teams struggle to find a home in siloed federal grant-funding system
• Map charts underground currents AI翻译
  作者：Brainard, Jeffrey