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作者：Brainard, Jeffrey
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作者：Ma, Zhangfeng; Zeng, Hongyu; Luo, Haipeng; Liu, Zemin; Jiang, Yu; Aoki, Yosuke; Wang, Weitao; Itoh, Yuji; Lyu, Mingzhe; Cui, Yan; Yun, Sang-Ho; Hill, Emma M.; Wei, Shengji
作者单位：Nanyang Technological University; Nanyang Technological University; Southern University of Science & Technology; China Earthquake Administration; Institute of Geophysics, CEA; University of Tokyo; Universite Gustave-Eiffel; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Savoie Mont Blanc; Hohai University; Nanyang Technological University; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS
摘要：The 2024 moment magnitude 7.5 Noto Peninsula (Japan) earthquake caused devastation to communities and was generated by a complex rupture process. Using space geodetic and seismic observations, we have shown that the event deformed the peninsula with a peak uplift reaching 5 meters at the west coast. Shallow slip exceeded 10 meters on an offshore fault. Peak stress drop was greater than 10 megapascals. This devastating event began with a slow rupture propagation lasting 15 to 20 seconds near it...
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作者：Pfau, David; Axelrod, Simon; Sutterud, Halvard; von Glehn, Ingrid; Spencer, James S.
作者单位：Alphabet Inc.; Google Incorporated; DeepMind; Imperial College London; Harvard University; Massachusetts Institute of Technology (MIT)
摘要：INTRODUCTION Understanding the physics of how matter interacts with light requires accurate modeling of electronic excited states of quantum systems. This underpins the behavior of photocatalysts, fluorescent dyes, quantum dots, light-emitting diodes (LEDs), lasers, solar cells, and more. Existing quantum chemistry methods for excited states can be much more inaccurate than those for ground states, sometimes qualitatively so, or can require prior knowledge targeted to specific states. Neural n...
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作者：Laman, Jon D.; Molloy, Michael; Noelle, Randolph J.
作者单位：University of Groningen; Dartmouth College
摘要：Discovered 30 years ago, CD40L antagonists are proving to be powerful autoimmune drugs
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作者：Cohen, Jon; Tsanni, Abdullahi
摘要：Mpox circulated in Nigeria for 8 years before it sparked a global outbreak. Could it have been stopped?
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作者：Rivera, J. Aguirre; Mao, G.; Sabantsev, A.; Panfilov, M.; Hou, Q.; Lindell, M.; Chanez, C.; Ritort, F.; Jinek, M.; Deindl, S.
作者单位：Uppsala University; Uppsala University; University of Zurich; University of Barcelona; University of Barcelona
摘要：Single-molecule techniques are ideally poised to characterize complex dynamics but are typically limited to investigating a small number of different samples. However, a large sequence or chemical space often needs to be explored to derive a comprehensive understanding of complex biological processes. Here we describe multiplexed single-molecule characterization at the library scale (MUSCLE), a method that combines single-molecule fluorescence microscopy with next-generation sequencing to enab...
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作者：Severins, Ivo; Bastiaanssen, Carolien; Kim, Sung Hyun; Simons, Roy B.; van Noort, John; Joo, Chirlmin
作者单位：Delft University of Technology; Leiden University - Excl LUMC; Leiden University; Ewha Womans University
摘要：At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but laborious assays impede functional screening of large sequence libraries. We introduce high-throughput Single-molecule Parallel Analysis for Rapid eXploration of Sequence space (SPARXS), integrating single-molecule fluorescence with next-generation sequencing. We applied SPARXS to study the sequenc...
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作者：Kaiser, Jocelyn
摘要：Six years into agency's efforts to curtail foreign interference, some say it should apologize
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作者：Minhas, Paras S.; Jones, Jeffrey R.; Latif-Hernandez, Amira; Sugiura, Yuki; Durairaj, Aarooran S.; Wang, Qian; Mhatre, Siddhita D.; Uenaka, Takeshi; Crapser, Joshua; Conley, Travis; Ennerfelt, Hannah; Jung, Yoo Jin; Liu, Ling; Prasad, Praveena; Jenkins, Brenita C.; Ay, Yeonglong Albert; Matrongolo, Matthew; Goodman, Ryan; Newmeyer, Traci; Heard, Kelly; Kang, Austin; Wilson, Edward N.; Yang, Tao; Ullian, Erik M.; Serrano, Geidy E.; Beach, Thomas G.; Wernig, Marius; Rabinowitz, Joshua D.; Suematsu, Makoto; Longo, Frank M.; McReynolds, Melanie R.; Gage, Fred H.; Andreasson, Katrin I.
作者单位：Stanford University; Stanford University; Salk Institute; Keio University; Keio University; Kyoto University; Stanford University; Princeton University; Princeton University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Francisco; Banner Research; Banner Health; Banner Sun Health Research Institute; Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University
摘要：INTRODUCTION Alzheimer's disease (AD) is an age-associated neurodegenerative disorder characterized by a progressive and irreversible loss of synapses and neural circuitry. Major pathophysiologic processes that contribute to synaptic loss, including disrupted proteostasis, accumulation of misfolded amyloid and tau, and microglial dysfunction, are being vigorously investigated with the goal of identifying disease-modifying therapies. However, coincident with these distinct pathologies is a sust...
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作者：Peterson, Christine
摘要：The research uses aerial imagery to pinpoint structures that could block migratory pronghorn and other wildlife
