6720期

最新文章

• Remote highland city upends ideas of urbanism AI翻译
  作者：Lawler, Andrew
• China unveils ambitious space plan AI翻译
  作者：Richter, Hannah
• Topological grain boundary segregation transitions AI翻译
  作者：Devulapalli, Vivek; Chen, Enze; Brink, Tobias; Frolov, Timofey; Liebscher, Christian H.
  作者单位：Max Planck Society; Stanford University; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Ruhr University Bochum; Ruhr University Bochum
  摘要：Engineering the structure of grain boundaries (GBs) by solute segregation is a promising strategy to tailor the properties of polycrystalline materials. Solute segregation triggering phase transitions at GBs has been suggested theoretically to offer different pathways to design interfaces, but an understanding of their intrinsic atomistic nature is missing. We combined atomic resolution electron microscopy and atomistic simulations to discover that iron segregation to GBs in titanium stabilize...
• Edit the messenger AI翻译
  作者：Leslie, Mitch
• Impact of CRISPR in cancer drug discovery AI翻译
  作者：Moffat, Jason; Komor, Alexis C.; Lum, Lawrence
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of California System; University of California San Diego; University of Texas System; University of Texas Southwestern Medical Center
• Group Releases Report on STEMM Workforce Barriers AI翻译
  作者：[Anonymous]
• A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase AI翻译
  作者：Cheng, Jiye; Venkatesh, Siddarth; Ke, Ke; Barratt, Michael J.; Gordon, Jeffrey I.
  作者单位：Washington University (WUSTL); Washington University (WUSTL)
  摘要：Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth. Here, we characterize a fatty acid amide hydrolase (FAAH) from a growth-associated intestinal strain of Faecalibacterium prausnitzii cultured from these children. This enzyme, expressed and purified from Escherichia coli, hydrolyzes a variety of N-acylam...
• Prevent the spread of Oropouche fever in Brazil AI翻译
  作者：Sansone, Nathalia Mariana Santos; Marques, Luiz Felipe Azevedo; Marson, Fernando Augusto Lima
• Imagination: A Manifesto AI翻译
  作者：Greenbaum, Dov
  作者单位：Reichman University; Reichman University; Yale University
• A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont AI翻译
  作者：Sheahan, Madeline L.; Flores, Katia; Coyne, Michael J.; Garcia-Bayona, Leonor; Chatzidaki-Livanis, Maria; Holst, Andrea Q.; Smith, Rita C.; Sundararajan, Anitha; Barquera, Blanca; Comstock, Laurie E.
  作者单位：University of Chicago; University of Chicago; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Technical University of Denmark; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Stanford University; University System of Ohio; Ohio University; Chr Hansen
  摘要：DNA transfer is ubiquitous in the human gut microbiota, especially among species of the order Bacteroidales. In silico analyses have revealed hundreds of mobile genetic elements shared between these species, yet little is known about the phenotypes they encode, their effects on fitness, or pleiotropic consequences for the recipient's genome. In this work, we show that acquisition of a ubiquitous integrative conjugative element (ICE) encoding a type VI secretion system (T6SS) shuts down the nat...