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作者：Frank, Christopher; Khoshouei, Ali; Fuss, Lara; Schiwietz, Dominik; Putz, Dominik; Weber, Lara; Zhao, Zhixuan; Hattori, Motoyuki; Feng, Shihao; de Stigter, Yosta; Ovchinnikov, Sergey; Dietz, Hendrik
作者单位：Technical University of Munich; Technical University of Munich; Fudan University; Changping Laboratory; Harvard University; Massachusetts Institute of Technology (MIT)
摘要：Machine learning (ML)-based design approaches have advanced the field of de novo protein design, with diffusion-based generative methods increasingly dominating protein design pipelines. Here, we report a hallucination-based protein design approach that functions in relaxed sequence space, enabling the efficient design of high-quality protein backbones over multiple scales and with broad scope of application without the need for any form of retraining. We experimentally produced and characteri...
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作者：Luo, Jian
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
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作者：Park, Matthew D.; Le Berichel, Jessica; Hamon, Pauline; Wilk, C. Matthias; Belabed, Meriem; Yatim, Nader; Saffon, Alexis; Boumelha, Jesse; Falcomata, Chiara; Tepper, Alexander; Hegde, Samarth; Mattiuz, Raphael; Soong, Brian Y.; Lamarche, Nelson M.; Rentzeperis, Frederika; Troncoso, Leanna; Halasz, Laszlo; Hennequin, Clotilde; Chin, Theodore; Chen, Earnest P.; Reid, Amanda M.; Su, Matthew; Cahn, Ashley Reid; Koekkoek, Laura L.; Venturini, Nicholas; Wood-isenberg, Shira; D'souza, Darwin; Chen, Rachel; Dawson, Travis; Nie, Kai; Chen, Zhihong; Kim-Schulze, Seunghee; Casanova-Acebes, Maria; Swirski, Filip K.; Downward, Julian; Vabret, Nicolas; Brown, Brian D.; Marron, Thomas U.; Merad, Miriam
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Universite Paris Cite; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Francis Crick Institute; University of London; University College London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Yale University; Yale University; Centro Nacional de Investigaciones Oncologicas (CNIO)
摘要：Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of interleukin (IL)-1 alpha, which drives the enhanced myeloid response. The age-associated decli...
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作者：Medellin, Rodrigo A.
作者单位：Universidad Nacional Autonoma de Mexico
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作者：Richter, Hannah
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作者：Richter, Hannah
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作者：Li, Yang; Wang, Yuanyuan; Tan, Yue-Qiu; Yue, Qiuling; Guo, Yueshuai; Yan, Ruoyu; Meng, Lanlan; Zhai, Huicong; Tong, Lingxiu; Yuan, Zihan; Li, Wu; Wang, Cuicui; Han, Shenglin; Ren, Sen; Yan, Yitong; Wang, Weixu; Gao, Lei; Tan, Chen; Hu, Tongyao; Zhang, Hao; Liu, Liya; Yang, Pinglan; Jiang, Wanyin; Ye, Yiting; Tan, Huanhuan; Wang, Yanfeng; Lu, Chenyu; Li, Xin; Xie, Jie; Yuan, Gege; Cui, Yiqiang; Shen, Bin; Wang, Cheng; Guan, Yichun; Li, Wei; Shi, Qinghua; Lin, Ge; Ni, Ting; Sun, Zheng; Ye, Lan; Vourekas, Anastasios; Guo, Xuejiang; Lin, Mingyan; Zheng, Ke
作者单位：Nanjing Medical University; Nanjing Medical University; Central South University; Nanjing University; Northwest A&F University - China; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Nanjing Medical University; Zhengzhou University; Guangzhou Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Fudan University; Fudan University; Baylor College of Medicine; Louisiana State University System; Louisiana State University; Nanjing Medical University
摘要：Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack of systematic understanding of RBPs in the mammalian testis, which harbors one of the most complex tissue transcriptomes. We adapted RNA interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers of dynamics along spermatogenesis. Trapping of RNA-cross-linked peptides showed that the glutamic acid-arginine (ER) patch, a residue-coevolved polyampholytic element present ...
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作者：Offord, Catherine
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作者：Xiao, Chuanlian; Wang, Hongguang; Usiskin, Robert; van Aken, Peter A.; Maier, Joachim
作者单位：Max Planck Society; Honeywell
摘要：Insertion storage in battery electrodes and supercapacitive storage are typically considered to be independent phenomena and thus are dealt with in separate scientific communities. Using tailored experiments on titanium oxide thin films of various thicknesses, we demonstrate the simultaneous occurrence of both processes. For the interpretation of the entire storage profile encompassing both contributions, the (free) energies of the charge carriers in the mixed conductor and the neighboring pha...
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作者：Thomas, Hannah; Chung, Yi Fei; Maron, Martine; Rhodes, Jonathan R.; Simmonds, Jeremy S.; Ward, Michelle S.; Williams, Brooke A.
作者单位：University of Queensland; University of Queensland; Queensland University of Technology (QUT); Griffith University
