2024

最新文章

• Wellcome aims to boost diversity AI翻译
  作者：Brainard, Jeffrey
• Degradation trumps mutations in cancer AI翻译
  作者：Davis, R. Eric; Westin, Jason R.
  作者单位：University of Texas System; UTMD Anderson Cancer Center
  摘要：Redirecting targeted proteins for degradation can overcome acquired drug resistance
• Baby in tow AI翻译
  作者：Hogan, Alexandra
  作者单位：University of New South Wales Sydney
• Nonopioid pain drug scores well AI翻译
  作者：Brainard, Jeffrey
• Type III-B CRISPR-Cas cascade of proteolytic cleavages AI翻译
  作者：Steens, Jurre A.; Bravo, Jack P. K.; Salazar, Carl Raymund P.; Yildiz, Caglar; Amieiro, Afonso M.; Kostlbacher, Stephan; Prinsen, Stijn H. P.; Andres, Ane S.; Patinios, Constantinos; Bardis, Andreas; Barendregt, Arjan; Scheltema, Richard A.; Ettema, Thijs J. G.; van der Oost, John; Taylor, David W.; Staals, Raymond H. J.
  作者单位：Wageningen University & Research; University of Texas System; University of Texas Austin; Utrecht University
  摘要：The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a set of associated genes of a type III-B system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT and PCaspase (prokaryotic caspase), co-opted from a cyclic oligonucleotide-based antiphage signaling system (CBASS). Cyclic tri-adenosine monophosphate (AMP)-induced ...
• Sustainability limits needed for CO2 removal AI翻译
  作者：Deprez, Alexandra; Leadley, Paul; Dooley, Kate; Williamson, Phil; Cramer, Wolfgang; Gattuso, Jean-Pierre; Rankovic, Aleksandar; Carlson, Eliot L.; Creutzig, Felix
  作者单位：AgroParisTech; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of Melbourne; University of East Anglia; Institut de Recherche pour le Developpement (IRD); Aix-Marseille Universite; Avignon Universite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut d'Etudes Politiques Paris (Sciences Po); Columbia University; Technical University of Berlin
  摘要：The true climate mitigation challenge is revealed by considering sustainability impacts
• Terminal C(sp3)-H borylation through intermolecular radical sampling AI翻译
  作者：Wang, Miao; Huang, Yahao; Hu, Peng
  作者单位：Sun Yat Sen University
  摘要：Hydrogen atom transfer (HAT) processes can overcome the strong bond dissociation energies (BDEs) of inert C(sp(3))-H bonds and thereby convert feedstock alkanes into value-added fine chemicals. Nevertheless, the high reactivity of HAT reagents, coupled with the small differences among various C(sp(3))-H bond strengths, renders site-selective transformations of straight-chain alkanes a great challenge. Here, we present a photocatalytic intermolecular radical sampling process for the iron-cataly...
• Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels AI翻译
  作者：Salameh, Luna Jammal; Bitzenhofer, Sebastian H.; Hanganu-Opatz, Ileana L.; Dutschmann, Mathias; Egger, Veronica
  作者单位：University of Regensburg; University of Hamburg; University Medical Center Hamburg-Eppendorf; University System of Ohio; Case Western Reserve University
  摘要：The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction w...
• Photosensitization enables Pauson-Khand-type reactions with nitrenes AI翻译
  作者：Li, Fang; Zhu, W. Felix; Empel, Claire; Datsenko, Oleksandr; Kumar, Adarsh; Xu, Yameng; Ehrler, Johanna H. M.; Atodiresei, Iuliana; Knapp, Stefan; Mykhailiuk, Pavel K.; Proschak, Ewgenij; Koenigs, Rene M.
  作者单位：RWTH Aachen University; Goethe University Frankfurt; Enamine Ltd; Goethe University Frankfurt; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv
  摘要：The Pauson-Khand reaction has in the past 50 years become one of the most common cycloaddition reactions in chemistry. Coupling two unsaturated bonds with carbon monoxide, the transformation remains limited to CO as a C1 building block. Herein we report analogous cycloaddition reactions with nitrenes as an N1 unit. The reaction of a nonconjugated diene with a nitrene precursor produces bicyclic bioisosteres of common saturated heterocycles such as piperidine, morpholine, and piperazine. Experi...
• Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage AI翻译
  作者：Liu, Zi-Xian; Zhang, Shouyue; Zhu, Han-Zhou; Chen, Zhi-Hang; Yang, Yun; Li, Long-Qi; Lei, Yuan; Liu, Yun; Li, Dan-Yuan; Sun, Ao; Li, Cheng-Ping; Tan, Shun-Qing; Wang, Gao-Li; Shen, Jie-Yi; Jin, Shuai; Gao, Caixia; Liu, Jun-Jie Gogo
  作者单位：Tsinghua University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Ribozymes are catalytic RNAs with diverse functions including self-splicing and polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and sequence-specific DNA endonucleases, which could be repurposed as DNA manipulation tools. Focused on bacterial group II-C introns, we found that many systems without intron-encoded protein propagate multiple copies in their resident genomes. These introns, named HYdrolytic Endonucleolytic Ribozymes (HYERs), cleaved RNA, singl...