Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

• 成果类型: Article
• 署名作者: Salameh, Luna Jammal; Bitzenhofer, Sebastian H.; Hanganu-Opatz, Ileana L.; Dutschmann, Mathias; Egger, Veronica
• 署名单位: University of Regensburg; University of Hamburg; University Medical Center Hamburg-Eppendorf; University System of Ohio; Case Western Reserve University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12265
• DOI: 10.1126/science.adk8511
• 发表日期: 2024-02-02
• 页码: 494-+
• 关键词: respiratory modulation; single units; piezo2; oscillations; perception; responses; stimulation; expression; rhythms; stretch

摘要

The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within similar to 20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception-for example, during arousal-within the olfactory bulb and possibly across various other brain areas.