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作者：[Anonymous]
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作者：[Anonymous]
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作者：Wagner, Zachary; Mohanan, Manoj; Zutshi, Rushil; Mukherji, Arnab; Sood, Neeraj
作者单位：RAND Corporation; RAND Corporation; Pardee RAND Graduate School; Duke University; Indian Institute of Management (IIM System); Indian Institute of Management Bangalore; University of Southern California; University of Southern California
摘要：Most health care providers in developing countries know that oral rehydration salts (ORS) are a lifesaving and inexpensive treatment for child diarrhea, yet few prescribe it. This know-do gap has puzzled experts for decades. Using randomized experiments in India, we estimated the extent to which ORS underprescription is driven by perceptions that patients do not want ORS, provider's financial incentives, and ORS stock-outs (out-of-stock events). Patients expressing a preference for ORS increas...
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作者：Gardner, Eric E.; Earlie, Ethan M.; Li, Kate; Thomas, Jerin; Hubisz, Melissa J.; Stein, Benjamin D.; Zhang, Chen; Cantley, Lewis C.; Laughney, Ashley M.; Varmus, Harold
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
摘要：Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform into SCLC after treatment with targeted therapies. In this study, we designed models to follow the conversion of LUAD to SCLC and found that the barrier to histological transformation converges on tolerance to Myc, which we implicate as a lineage-specific driver of the pulmonary neuroendocrine cell. Histological ...
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作者：Voosen, Paul
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作者：Yamamoto, Keith R.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：The world is continuously being transformed by science and technology (S&T), but to deliver equitable benefits to the public, scientists must be embedded in influential sectors of society-policy, diplomacy, journalism, law, business, education, and more. This means injecting PhD-level experts at every stage of research and development, from ideation, investigation, and investment to manufacture, deployment, regulation, and after-market evaluation.
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作者：Guimaraes, Eduardo Linck; Dias, David Oliveira; Hau, Wing Fung; Julien, Anais; Holl, Daniel; Garcia-Collado, Maria; Savant, Soniya; Vagesjo, Evelina; Phillipson, Mia; Jakobsson, Lars; Goritz, Christian
作者单位：Karolinska Institutet; Karolinska Institutet; Uppsala University
摘要：Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that enlarges upon vasodilation, but its regulation is not completely understood. Here, we show that perivascular fibroblasts in the corpora cavernosa support vasodilation by reducing norepinephrine availability. The effect on penile blood flow depends on the number of fibroblasts, which is regulated by erectile activity. Erection dynamically alters the positional arrangement of fibroblasts, temporarily down-r...
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Savitsky, Zack
