-
作者：Lim, So-Yon; Lee, Jina; Osuna, Christa E.; Vikhe, Pratik; Schalk, Dane R.; Chen, Elsa; Fray, Emily; Kumar, Mithra; Schultz-Darken, Nancy; Rakasz, Eva; Capuano, Saverio; Ladd, Ruby A.; Gil, Hwi Min; Evans, David T.; Jeng, Emily K.; Seaman, Michael; Martin, Malcolm; Van Dorp, Christiaan; Perelson, Alan S.; Wong, Hing C.; Siliciano, Janet D.; Siliciano, Robert; Safrit, Jeffrey T.; Nixon, Douglas F.; Soon-Shiong, Patrick; Nussenzweig, Michel; Whitney, James B.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Wisconsin System; University of Wisconsin Madison; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); United States Department of Energy (DOE); Los Alamos National Laboratory; Johns Hopkins University; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine; Rockefeller University; Howard Hughes Medical Institute; Rockefeller University; Boston College; Emory University; NewYork-Presbyterian Hospital; Columbia University
摘要：The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we demonstrate that the administration of N-803 (brand name Anktiva) and broadly neutralizing antibodies (bNAbs) results in sustained viral control after discontinuation of antiretroviral therapy (ART) in simian-human AD8 (SHIV-AD8)-infected, ART-suppressed rhesus macaques. N-803+bNAbs treatment induced immune activation and transient viremia but onl...
-
作者：Malanoski, Cooper M.; Farnsworth, Alex; Lunt, Daniel J.; Valdes, Paul J.; Saupe, Erin E.
作者单位：University of Oxford; University of Bristol
摘要：Anthropogenic climate change is increasing rapidly and already impacting biodiversity. Despite itsimportance in future projections, understanding of the underlying mechanisms by which climatemediates extinction remains limited. We present an integrated approach examining the roleof intrinsic traits versus extrinsic climate change in mediating extinction risk for marineinvertebrates over the past 485 million years. We found that a combination of physiologicaltraits and the magnitude of climate ...
-
作者：Pennisi, Elizabeth
摘要：Understudied means of regulating genes is likely widespread in butterflies-and perhaps other animals
-
作者：Sharma, Shonit Nair; Lee, Yuhan
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School
摘要：The ubiquity of phrases such as high blood pressure or low blood sugar not only indicates their integration into our personal perception of health but also underscores the societal importance of the medical technologies that enable their measurement. In modern medicine, devices that can monitor biological changes in cells and organs are essential to understanding, diagnosing, and managing disease. However, many limitations exist in current monitoring devices, particularly in those that aim to ...
-
作者：Bufe, Aaron; Rugenstein, Jeremy K. C.; Hovius, Niels
作者单位：University of Munich; Colorado State University System; Colorado State University Fort Collins; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; University of Potsdam
摘要：Uplift and erosion modulate the carbon cycle over geologic timescales by exposing minerals to chemical weathering. However, the erosion sensitivity of mineral weathering remains difficult to quantify. Solute-chemistry datasets from mountain streams in different orogens isolate the impact of erosion on silicate weathering-a carbon dioxide (CO2) sink-and coupled sulfide and carbonate weathering-a CO2 source. Contrasting erosion sensitivities of these reactions produce a CO2-drawdown maximum at e...
-
作者：Davis, Charles C.
作者单位：Harvard University
摘要：Last month, Duke University in North Carolina announced that it was shuttering its herbarium. The collection consists of nearly 1 million specimens representing the most comprehensive and historic set of plants from the southeastern United States. It also includes extensive holdings from other regions of the world, especially Mexico, Central America, and the West Indies. Duke plans to disperse these samples to other institutions for use or storage over the next 2 to 3 years, but this decision ...
-
作者：Brainard, Jeffrey
-
作者：Brainard, Jeffrey
-
作者：Kaur, Rupinder; Mcgarry, Angelina; Shropshire, J. Dylan; Leigh, Brittany A.; Bordenstein, Seth R.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Vanderbilt University; Lehigh University
摘要：The extent to which prophage proteins interact with eukaryotic macromolecules is largely unknown. In this work, we show that cytoplasmic incompatibility factor A (CifA) and B (CifB) proteins, encoded by prophage WO of the endosymbiont Wolbachia, alter long noncoding RNA (lncRNA) and DNA during Drosophila sperm development to establish a paternal-effect embryonic lethality known as cytoplasmic incompatibility (CI). CifA is a ribonuclease (RNase) that depletes a spermatocyte lncRNA important for...
-
作者：Wake, Marvalee H.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：During their evolution, amphibians have performed diverse and sometimes bizarre natural experiments in reproductive biology. Most members of the class, which includes frogs, salamanders, and caecilians, retain certain ancestral features, including courtship, external fertilization, egg laying (oviparity), hatching of larvae, metamorphosis in water, and emerging terrestrially. However, many frogs, salamanders, and especially caecilians have developed distinct and complex modes of egg protection...
