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作者：Tierney, Matthew T.; Polak, Lisa; Yang, Yihao; Abdusselamoglu, Merve Deniz; Baek, Inwha; Stewart, Katherine S.; Fuchs, Elaine
作者单位：Rockefeller University; Howard Hughes Medical Institute; Kyung Hee University
摘要：Lineage plasticity-a state of dual fate expression-is required to release stem cells from their niche constraints and redirect them to tissue compartments where they are most needed. In this work, we found that without resolving lineage plasticity, skin stem cells cannot effectively generate each lineage in vitro nor regrow hair and repair wounded epidermis in vivo. A small-molecule screen unearthed retinoic acid as a critical regulator. Combining high-throughput approaches, cell culture, and ...
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作者：Brainard, Jeffrey
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作者：Park, Jaehong; Choi, Seonmi; Takatoh, Jun; Zhao, Shengli; Harrahill, Andrew; Han, Bao-Xia; Wang, Fan
作者单位：Massachusetts Institute of Technology (MIT); Duke University; Duke University
摘要：Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAmVOC) in adult mice as being both necessary and sufficient for driving vocal cord closure and eliciting mouse ultrasonic vocalizations (USVs). The duration of RAmVOC activation can determine the leng...
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作者：Yarahmadi, Hossein; Khorsandi, Zahra
作者单位：Isfahan University of Technology
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作者：Anthony, Raymond; Miller, David S.; Hoenig, Donald E.; Millar, Kate M.; Goodwin, Jean; Dean, Wesley R.; Grimm, Herwig; Meijboom, Franck L. B.; Murphy, Julia; Persico Murphy, Elyse; Scott, H. Morgan; De Paula Vieira, Andreia
作者单位：University of Alaska System; University of Alaska Anchorage; University of Nottingham; University of Nottingham; North Carolina State University; University of Copenhagen; Medical University of Vienna; University of Vienna; University of Veterinary Medicine Vienna; Utrecht University; Texas A&M University System; Texas A&M University College Station
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作者：Brainard, Jeffrey
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作者：Cardoso, Pedro; Fukushima, Caroline S.; Maxhelaku, Armela; Poczai, Peter; Porto, Miguel; Puksas, Andrius; Reino, Luis; Saar, Indrek; Stringham, Oliver; Toomes, Adam; Vargas, Thiago; Verissimo, Diogo
作者单位：Universidade de Lisboa; Universidade de Lisboa; University of Helsinki; University of Turku; University of Tirana (UT); University of Helsinki; Universidade de Lisboa; Universidade do Porto; Vytautas Magnus University; Estonian Academy of Security Sciences; Tallinn University; Rutgers University System; Rutgers University New Brunswick; University of Adelaide; University of Oxford
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作者：Rolland, Antoine; Heffernan, Brendan M.
摘要：A single photonic device accommodates three different modes of operation
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作者：Vandael, David; Jonas, Peter
作者单位：Institute of Science & Technology - Austria
摘要：The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this ...
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作者：Heidt, Amanda
摘要：The fish's genomes change so slowly that species separated since the dinosaurs can produce fertile hybrids today
