2024

最新文章

• Utah flouts FDA with new placental stem cell law AI翻译
  作者：Wadman, Meredith
  摘要：Measure declares that patients can be given unapproved treatments
• Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages AI翻译
  作者：Liebold, Imke; Al Jawazneh, Amirah; Casar, Christian; Lanzloth, Clarissa; Leyk, Stephanie; Hamley, Madeleine; Wong, Milagros N.; Kylies, Dominik; Graefe, Stefanie K.; Edenhofer, Ilka; Aranda-Pardos, Irene; Kriwet, Marie; Haas, Helmuth; Krause, Jenny; Hadjilaou, Alexandros; Schromm, Andra B.; Richardt, Ulricke; Eggert, Petra; Tappe, Dennis; Weidemann, Soeren A.; Ghosh, Sourav; Krebs, Christian F.; A-Gonzalez, Noelia; Worthmann, Anna; Lohse, Ansgar W.; Huber, Samuel; Rothlin, Carla V.; Puelles, Victor G.; Jacobs, Thomas; Gagliani, Nicola; Bosurgi, Lidia
  作者单位：University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Aarhus University; Aarhus University; University of Munster; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Forschungszentrum Borstel; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; University of Hamburg; University Medical Center Hamburg-Eppendorf; Yale University; Yale University; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Yale University; University of Hamburg; University Medical Center Hamburg-Eppendorf
  摘要：Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling signature. Engulfment of apoptotic hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis of T cells had little effect on IL-4-induced gene e...
• Sister chromatid cohesion establishment during DNA replication termination AI翻译
  作者：Cameron, George; Gruszka, Dominika T.; Gruar, Rhian; Xie, Sherry; Kaya, Cagla; Nasmyth, Kim A.; Baxter, Jonathan; Srinivasan, Madhusudhan; Yardimci, Hasan
  作者单位：Francis Crick Institute; University of Oxford; University of Sussex; University of Oxford; University of Oxford
  摘要：Newly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion coordinates with DNA replication is poorly understood. Prevailing models suggest that cohesin complexes, bound to DNA before replication, remain behind the advancing replication fork to keep sister chromatids together. By visualizing single replication forks colliding with preloaded cohesin complexes, we find that the replisome instead pushes cohesin to where a converging replisome is...
• Planting a chemical flag on antigens AI翻译
  作者：Kunjapur, Aditya M.
  作者单位：University of Delaware
  摘要：Next-generation live vaccines are created by autonomous production of nitrated antigens
• De novo design of drug-binding proteins with predictable binding energy and specificity AI翻译
  作者：Lu, Lei; Gou, Xuxu; Tan, Sophia K.; Mann, Samuel I.; Yang, Hyunjun; Zhong, Xiaofang; Gazgalis, Dimitrios; Valdiviezo, Jesus; Jo, Hyunil; Wu, Yibing; Diolaiti, Morgan E.; Ashworth, Alan; Polizzi, Nicholas F.; DeGrado, William F.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California Riverside; University of California System; University of California San Francisco; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School
  摘要：The de novo design of small molecule-binding proteins has seen exciting recent progress; however, high-affinity binding and tunable specificity typically require laborious screening and optimization after computational design. We developed a computational procedure to design a protein that recognizes a common pharmacophore in a series of poly(ADP-ribose) polymerase-1 inhibitors. One of three designed proteins bound different inhibitors with affinities ranging from <5 nM to low micromolar. X-ra...
• Regulating advanced artificial agents AI翻译
  作者：Cohen, Michael K.; Kolt, Noam; Bengio, Yoshua; Hadfield, Gillian K.; Russell, Stuart
  作者单位：University of California System; University of California Berkeley; University of Toronto; Universite de Montreal; Mila Quebec Artificial Intelligence Institute; Vector Institute for Artificial Intelligence
  摘要：Governance frameworks should address the prospect of AI systems that cannot be safely tested
• Don't bury Mexico's biodiversity capacity AI翻译
  作者：Medellin, Rodrigo A.; Soberon, Jorge
  作者单位：Universidad Nacional Autonoma de Mexico; University of Kansas
  摘要：In a world where biodiversity is on the line on many fronts-from armed conflict to pandemics to climate change-defending institutions that have effectively managed it is paramount. In the global effort to protect biodiversity, Mexico has been at the forefront. In particular, for more than 30 years, Mexico's National Commission for the Knowledge and Use of Biodiversity (CONABIO) has promoted research, compiled information on the biodiversity of Mexico and elsewhere, and connected academia, gove...
• Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics AI翻译
  作者：Noto Guillen, Mariana; Li, Carmen; Rosener, Brittany; Mitchell, Amir
  作者单位：University of Massachusetts System; University of Massachusetts Worcester
  摘要：Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic screens with thousands of barcoded Escherichia coli knockouts. We analyzed 2 million gene-drug interactions underlying drug-specific toxicity. Network-based analysis of drug-drug similarities revealed that antibiotics clustered into modules that ...
• Lifelong persistence of nuclear RNAs in the mouse brain AI翻译
  作者：Zocher, Sara; Mccloskey, Asako; Karasinsky, Anne; Schulte, Roberta; Friedrich, Ulrike; Lesche, Mathias; Rund, Nicole; Gage, Fred H.; Hetzer, Martin W.; Toda, Tomohisa
  作者单位：Technische Universitat Dresden; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Salk Institute; Technische Universitat Dresden; German Center for Diabetes Research (DZD); Technische Universitat Dresden; Carl Gustav Carus University Hospital; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technische Universitat Dresden; Salk Institute; Institute of Science & Technology - Austria; University of Erlangen Nuremberg
  摘要：Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific ...
• Joint environmental and social benefits from diversified agriculture AI翻译
  作者：Rasmussen, Laura Vang; Grass, Ingo; Mehrabi, Zia; Smith, Olivia M.; Bezner-Kerr, Rachel; Blesh, Jennifer; Garibaldi, Lucas Alejandro; Isaac, Marney E.; Kennedy, Christina M.; Wittman, Hannah; Batary, Peter; Buchori, Damayanti; Cerda, Rolando; Chara, Julian; Crowder, David W.; Darras, Kevin; Demaster, Kathryn; Garcia, Karina; Gomez, Manuel; Gonthier, David; Hidayat, Purnama; Hipolito, Juliana; Hirons, Mark; Hoey, Lesli; James, Dana; John, Innocensia; Jones, Andrew D.; Karp, Daniel S.; Kebede, Yodit; Kerr, Carmen Bezner; Klassen, Susanna; Kotowska, Martyna; Kreft, Holger; Llanque, Ramiro; Levers, Christian; Lizcano, Diego J.; Lu, Adrian; Madsen, Sidney; Marques, Rosebelly Nunes; Martins, Pedro Buss; Melo, America; Nyantakyi-Frimpong, Hanson; Olimpi, Elissa M.; Owen, Jeb P.; Pantevez, Heiber; Qaim, Matin; Redlich, Sarah; Scherber, Christoph; Sciligo, Amber R.; Snapp, Sieglinde; Snyder, William E.; Steffan-Dewenter, Ingolf; Stratton, Anne Elise; Taylor, Joseph M.; Tscharntke, Teja; Valencia, Vivian; Vogel, Cassandra; Kremen, Claire
  作者单位：University of Copenhagen; University Hohenheim; University Hohenheim; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Michigan State University; Michigan State University; Cornell University; University of Michigan System; University of Michigan; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Toronto; Nature Conservancy; University of British Columbia; University of British Columbia; HUN-REN; HUN-REN Centre for Ecological Research; Bogor Agricultural University; CATIE - Centro Agronomico Tropical de Investigacion y Ensenanza; Washington State University; INRAE; University of California System; University of California Berkeley; University of Kentucky; Bogor Agricultural University; Universidade Federal da Bahia; Universidade Federal de Vicosa; Institute Nacional de Pesquisas da Amazonia; University of Oxford; University of Michigan System; University of Michigan; University of Dar es Salaam; University of Michigan System; University of Michigan; University of California System; University of California Davis; Institut Agro; Montpellier SupAgro; CIRAD; Institut de Recherche pour le Developpement (IRD); INRAE; Universite de Montpellier; University of Toronto; University of Victoria; University of Gottingen; University of Gottingen; Vrije Universiteit Amsterdam; Johann Heinrich von Thunen Institute; Nature Conservancy; Universidade de Sao Paulo; University of Denver; University of Bonn; University of Wurzburg; Zoologisches Forschungsmuseum Alexander Koenig (ZFMK); University of Bonn; CGIAR; International Maize & Wheat Improvement Center (CIMMYT); University System of Georgia; University of Georgia; University Hohenheim; University of Gottingen; Wageningen University & Research; Bishops University; Swedish University of Agricultural Sciences; University of British Columbia
  摘要：Agricultural simplification continues to expand at the expense of more diverse forms of agriculture. This simplification, for example, in the form of intensively managed monocultures, poses a risk to keeping the world within safe and just Earth system boundaries. Here, we estimated how agricultural diversification simultaneously affects social and environmental outcomes. Drawing from 24 studies in 11 countries across 2655 farms, we show how five diversification strategies focusing on livestock...