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作者：Thorp, H. Holden
摘要：All brains work differently. Individuals process information and engage with the world in ways that are influenced by a multitude of biological, cultural, and social factors. In the world of science, these differences are what spark innovation. This is why the scientific community needs to better recognize the enormous potential of neurodiversity and bear in mind that certain behavioral and cognitive traits that may strike some as unusual can be catalytic to the scientific quest.
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作者：Brainard, Jeffrey
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作者：Giampazolias, Evangelos; Pereira da Costa, Mariana; Lam, Khiem C.; Lim, Kok Haw Jonathan; Cardoso, Ana; Piot, Cecile; Chakravarty, Probir; Blasche, Sonja; Patel, Swara; Biram, Adi; Castro-Dopico, Tomas; Buck, Michael D.; Rodrigues, Richard R.; Poulsen, Gry Juul; Palma-Duran, Susana A.; Rogers, Neil C.; Koufaki, Maria A.; Minutti, Carlos M.; Wang, Pengbo; Vdovin, Alexander; Frederico, Bruno; Childs, Eleanor; Lee, Sonia; Simpson, Ben; Iseppon, Andrea; Omenetti, Sara; Kelly, Gavin; Goldstone, Robert; Nye, Emma; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Macrae, James I.; Zelenay, Santiago; Patil, Kiran Raosaheb; Litchfield, Kevin; Lee, James C.; Jess, Tine; Goldszmid, Romina S.; Sousa, Caetano
作者单位：Francis Crick Institute; Cancer Research UK; University of Manchester; National Institutes of Health (NIH) - USA; NIH Center for Cancer Research (CCR); NIH National Cancer Institute (NCI); Imperial College London; Francis Crick Institute; University of Cambridge; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Aalborg University; Francis Crick Institute; University of Manchester; Cancer Research UK; University of London; University College London; Francis Crick Institute; Francis Crick Institute; University of London; University of London Royal Veterinary College; Francis Crick Institute; University of London; University College London; UCL Medical School; Royal Free London NHS Foundation Trust; Christie NHS Foundation Trust; Fundacao Champalimaud
摘要：A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is at...
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作者：Zhu, Ziai; Sun, Xin
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：The respiratory tract is essential for breathing but is also important for detecting and responding to inhaled harmful (noxious) stimuli, such as pollutants, pathogens, water, and acid. Neuroendocrine cells (NECs)-rare epithelial cells that share characteristics with neurons-are an integral component of this sensory surveillance system ( 1 ). Although NECs have been proposed to act as airway sentinels capable of perceiving chemical and mechanical cues and can secrete signals to relay informati...
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作者：Avdellidou, Chrysa; Delbo', Marco; Nesvorny, David; Walsh, Kevin J.; Morbidelli, Alessandro
作者单位：Universite Cote d'Azur; Observatoire de la Cote d'Azur; University of Leicester; Southwest Research Institute; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; College de France
摘要：The giant planets of the Solar System formed on initially compact orbits, which transitioned to the current wider configuration by means of an orbital instability. The timing of that instability is poorly constrained. In this work, we use dynamical simulations to demonstrate that the instability implanted planetesimal fragments from the terrestrial planet region into the asteroid main belt. We use meteorite data to show that the implantation occurred >60 million years (Myr) after the Solar Sys...
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作者：Wen, Tai-Hao; Hung, Je-Min; Huang, Wei-Hsing; Jhang, Chuan-Jia; Lo, Yun-Chen; Hsu, Hung-Hsi; Ke, Zhao-En; Chen, Yu-Chiao; Chin, Yu-Hsiang; Su, Chin-, I; Khwa, Win-San; Lo, Chung-Chuan; Liu, Ren-Shuo; Hsieh, Chih-Cheng; Tang, Kea-Tiong; Ho, Mon-Shu; Chou, Chung-Cheng; Chih, Yu-Der; Chang, Tsung-Yung Jonathan; Chang, Meng-Fan
作者单位：Taiwan Semiconductor Manufacturing Company
摘要：Artificial intelligence (AI) edge devices prefer employing high-capacity nonvolatile compute-in-memory (CIM) to achieve high energy efficiency and rapid wakeup-to-response with sufficient accuracy. Most previous works are based on either memristor-based CIMs, which suffer from accuracy loss and do not support training as a result of limited endurance, or digital static random-access memory (SRAM)-based CIMs, which suffer from large area requirements and volatile storage. We report an AI edge p...
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作者：Casanova, Jean-Laurent; MacMicking, John D.; Nathan, Carl F.
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Yale University; Yale University; Yale University; Yale University; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine
摘要：Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon-gamma (IFN-gamma), a protein secreted by lymphocytes. Forty years ago, IFN-gamma was identified as a macrophage-activating factor, and, in recent years, there has been...
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作者：Lemaire, Patrick; Massol, Francois
摘要：France is at a crossroads, facing environmental and social challenges that are profoundly altering its society. Yet, the French government keeps prioritizing short-term political gains over long-term evidence-based planning for major transitions that France, like most countries, will undergo over the next 20 years. There is an urgent need for France to implement long-term science-informed policy-making.
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作者：Peng, Yangfan; Bjelde, Antje; Aceituno, Pau Vilimelis; Mittermaier, Franz X.; Planert, Henrike; Grosser, Sabine; Onken, Julia; Faust, Katharina; Kalbhenn, Thilo; Simon, Matthias; Radbruch, Helena; Fidzinski, Pawel; Schmitz, Dietmar; Alle, Henrik; Holtkamp, Martin; Vida, Imre; Grewe, Benjamin F.; Geiger, Joerg R. P.
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Evangelical Hospital Bethel (EvKB) - House Gilead I; University of Bielefeld; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and ide...
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作者：Ellis, Erle C.
作者单位：University System of Maryland; University of Maryland Baltimore County; University of Oxford
