作者：Pereira, Henrique M.; Martins, Ines S.; Rosa, Isabel M. D.; Kim, Hyejin; Leadley, Paul; Popp, Alexander; van Vuuren, Detlef P.; Hurtt, George; Quoss, Luise; Arneth, Almut; Baisero, Daniele; Bakkenes, Michel; Chaplin-Kramer, Rebecca; Chini, Louise; Di Marco, Moreno; Ferrier, Simon; Fujimori, Shinichiro; Guerra, Carlos A.; Harfoot, Michael; Harwood, Thomas D.; Hasegawa, Tomoko; Haverd, Vanessa; Havlik, Petr; Hellweg, Stefanie; Hilbers, Jelle P.; Hill, Samantha L. L.; Hirata, Akiko; Hoskins, Andrew J.; Humpenoeder, Florian; Janse, Jan H.; Jetz, Walter; Johnson, Justin A.; Krause, Andreas; Leclere, David; Matsui, Tetsuya; Meijer, Johan R.; Merow, Cory; Obersteiner, Michael; Ohashi, Haruka; De Palma, Adriana; Poulter, Benjamin; Purvis, Andy; Quesada, Benjamin; Rondinini, Carlo; Schipper, Aafke M.; Settele, Josef; Sharp, Richard; Stehfest, Elke; Strassburg, Bernardo B. N.; Takahashi, Kiyoshi; Talluto, Matthew V.; Thuiller, Wilfried; Titeux, Nicolas; Visconti, Piero; Ware, Christopher; Wolf, Florian; Alkemade, Rob
作者单位：German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Martin Luther University Halle Wittenberg; Universidade do Porto; University of York - UK; UK Centre for Ecology & Hydrology (UKCEH); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); AgroParisTech; Potsdam Institut fur Klimafolgenforschung; Universitat Kassel; Utrecht University; University System of Maryland; University of Maryland College Park; Helmholtz Association; Karlsruhe Institute of Technology; Sapienza University Rome; BirdLife International; World Wildlife Fund; University of Minnesota System; University of Minnesota Twin Cities; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; Kyoto University; National Institute for Environmental Studies - Japan; Universidade de Coimbra; University of Oxford; Ritsumeikan University; International Institute for Applied Systems Analysis (IIASA); Swiss Federal Institutes of Technology Domain; ETH Zurich; Radboud University Nijmegen; Natural History Museum London; Forestry & Forest Products Research Institute - Japan; University of Tsukuba; James Cook University; Yale University; Yale University; University of Minnesota System; University of Minnesota Twin Cities; Technical University of Munich; University of Connecticut; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Imperial College London; Universidad del Rosario; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); University of the Philippines System; University of the Philippines Los Banos; University of Innsbruck; Universite Gustave-Eiffel; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Luxembourg Institute of Science & Technology; Zoological Society of London; University of London; University College London; Wageningen University & Research
摘要：Based on an extensive model intercomparison, we assessed trends in biodiversity and ecosystem services from historical reconstructions and future scenarios of land-use and climate change. During the 20th century, biodiversity declined globally by 2 to 11%, as estimated by a range of indicators. Provisioning ecosystem services increased several fold, and regulating services decreased moderately. Going forward, policies toward sustainability have the potential to slow biodiversity loss resulting...
作者：Dudnyk, Kseniia; Cai, Donghong; Shi, Chenlai; Xu, Jian; Zhou, Jian
作者单位：University of Texas System; University of Texas Southwestern Medical Center; St Jude Children's Research Hospital
摘要：INTRODUCTION The promoter is responsible for initiating the transcription process and is an essential part of any gene. However, present understanding of how promoter sequence drives transcription initiation is still incomplete and cannot explain most human promoters. RATIONALE Each promoter has a distinct profile of transcription initiation signals that show the frequency and position of transcription start sites and can be experimentally measured at base-pair resolution. We hypothesized that...
作者：Offensperger, Fabian; Tin, Gary; Duran-Frigola, Miquel; Hahn, Elisa; Dobner, Sarah; am Ende, Christopher W.; Strohbach, Joseph W.; Rukavina, Andrea; Brennsteiner, Vincenth; Ogilvie, Kevin; Marella, Nara; Kladnik, Katharina; Ciuffa, Rodolfo; Majmudar, Jaimeen D.; Field, S. Denise; Bensimon, Ariel; Ferrari, Luca; Ferrada, Evandro; Ng, Amanda; Zhang, Zhechun; Degliesposti, Gianluca; Boeszoermenyi, Andras; Martens, Sascha; Stanton, Robert; Mueller, Andre C.; Hannich, J. Thomas; Hepworth, David; Superti-Furga, Giulio; Kubicek, Stefan; Schenone, Monica; Winter, Georg E.
作者单位：Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Pfizer; Pfizer USA; Pfizer; Pfizer USA; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Pfizer; Pfizer USA; Medical University of Vienna
摘要：INTRODUCTION Chemical modulation of protein function is an important experimental approach to illuminate biological mechanisms and represents the most frequently used strategy to treat human disease. Nevertheless, around 80% of the human proteome lacks annotated small-molecule ligands, thus leaving many proteins, including validated disease targets, outside the reach of mechanistic elucidation and therapeutic innovation. RATIONALE To close this gap, unbiased approaches to advance ligand discov...
作者：Slabbekoorn, Hans
作者单位：Leiden University - Excl LUMC; Leiden University
摘要：Long-term impact from prenatal noise exposure in birds should raise general concern
作者：Brosnan, Sarah F.
作者单位：University System of Georgia; Georgia State University; University System of Georgia; Georgia State University
作者：Unsworth, R. K. F.; Jones, B. L. H.
作者单位：Swansea University; State University System of Florida; Florida International University
