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作者:Galloway, Katie; Johnstone, Christopher
作者单位:Massachusetts Institute of Technology (MIT)
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作者:Kim, Joon-Seok; Kim, Joonyun; Yang, Dae-Jin; Shim, Jaewoo; Hu, Luhing; Lee, Chang-Seok; Kim, Jeehwan; Kim, Sang Won
作者单位:Samsung; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Hongik University
摘要:The advancement in semiconductor technology through the integration of more devices on a chip has reached a point where device scaling alone is no longer an efficient way to improve the device performance. One issue lies in the interconnects connecting the transistors, in which the resistivity of metals increases exponentially as their dimensions are scaled down to match those of the transistors. As a result, the total signal processing delay is dominated by the resistance-capacitance (RC) del...
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作者:Niu, Yujie; Knops, Johannes M. H.; Hua, Limin; Jentsch, Anke
作者单位:Gansu Agricultural University; University of Bayreuth
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作者:Cho, Adrian
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作者:Lachs, Liam; Bozec, Yves-Marie; Bythell, John C.; Donner, Simon D.; East, Holly K.; Edwards, Alasdair J.; Golbuu, Yimnang; Gouezo, Marine; Guest, James R.; Humanes, Adriana; Riginos, Cynthia; Mumby, Peter J.
作者单位:Newcastle University - UK; University of British Columbia; University of British Columbia; University of Queensland; Northumbria University; Southern Cross University; Australian Institute of Marine Science
摘要:Marine heatwaves are intensifying under climate change, exposing populations of reef-building corals to mass mortality and intense selective pressure. It remains unknown whether adaptation can keep pace with warming and maintain reef functioning. We have developed an eco-evolutionary metapopulation model for Acropora, an ecologically important yet thermally sensitive coral taxon. We found that, although corals have some adaptation capacity, they will suffer severe heatwave-induced declines ove...
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作者:Lynham, John; Villasenor-Derbez, Juan Carlos
作者单位:University of Hawaii System; University of Hawaii Manoa; Stanford University; University of Miami; University of Miami
摘要:Global tuna fisheries are valued at more than $40 billion, with the majority of this value derived from purse seine fisheries. Recently created large-scale marine protected areas are potentially big enough to protect highly migratory species such as tuna, possibly leading to increases in abundance (a conservation benefit) and consequent spillover near protected area boundaries (an economic benefit). Using publicly available data from nine large-scale marine protected areas across the Pacific a...
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作者:Thorp, H. Holden
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作者:Baghdadi, Meryem B.; Houtekamer, Ronja M.; Perrin, Louisiane; Rao-Bhatia, Abilasha; Whelen, Myles; Decker, Linda; Bergert, Martin; Perez-Gonzalez, Carlos; Bouras, Reda; Gropplero, Giacomo; Loe, Adrian K. H.; Afkhami-Poostchi, Amin; Chen, Xin; Huang, Xi; Descroix, Stephanie; Wrana, Jeffrey L.; Diz-Munoz, Alba; Gloerich, Martijn; Ayyaz, Arshad; Matic Vignjevic, Danijela; Kim, Tae-Hee
作者单位:Sorbonne Universite; Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Toronto; Hospital for Sick Children (SickKids); Utrecht University; Utrecht University Medical Center; University of Toronto; University of Calgary; University of Calgary; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; UNICANCER; Institut Curie; Sorbonne Universite; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; Saint Michaels Hospital Toronto
摘要:Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we investigated the roles of PIEZO mechanosensitive channels in the intestinal stem cell (ISC) niche. We used mouse genetics and single-cell RNA sequencing analysis to assess the requirement for PIEZO channels in ISC maintenance. In vivo measurement of basement membrane stiffness showed that ISCs res...
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作者:Kupferschmidt, Kai
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作者:Else, Holly
摘要:Systematic reviews that aim to extract broad conclusions from many studies are in peril.