作者：Li, Melissa; Li, Qitong; Brongersma, Mark L.; Atwater, Harry A.
作者单位：California Institute of Technology; Stanford University
作者：Hwang, Cheinway; Yu, Daocheng
作者单位：National Yang Ming Chiao Tung University; Liaoning Technical University
作者：Akiki, Rose Marie; Cornbrooks, Rebecca G.; Magami, Kosuke; Greige, Alain; Snyder, Kirsten K.; Wood, Daniel J.; Herrington, Mary Claire; Mace, Philip; Blidy, Kyle; Koike, Nobuya; Berto, Stefano; Cowan, Christopher W.; Taniguchi, Makoto
作者单位：Medical University of South Carolina; Medical University of South Carolina; Kyoto Prefectural University of Medicine
摘要：Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4 (neuronal PAS domain protein 4). Here we show that a conserved long noncoding enhancer RNA (lnc-eRNA), transcribed from an activity-sensitive enhancer, produces DNA:RNA hybrid R-loop structures t...
