2024

最新文章

• CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication AI翻译
  作者：McKenney, Connor; Lendner, Yovel; Zuniga, Adler Guerrero; Sinha, Niladri; Veresko, Benjamin; Aikin, Timothy J.; Regot, Sergi
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
  摘要：Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G(1)) to synthesis (S) phase transition of the cell cycle by responding to mitogen signaling, promoting E2F transcription and inhibition of the anaphase-promoting complex. We found that this mechanism was still required in G(2)-arrested cells to prevent cell cycle exit after the S phase. This mechanism revealed a role for CDK4/6 in maintaining the G(2) sta...
• Locally narrow droplet size distributions are ubiquitous in stratocumulus clouds AI翻译
  作者：Allwayin, Nithin; Larsen, Michael L.; Glienke, Susanne; Shaw, Raymond A.
  作者单位：Michigan Technological University; College of Charleston; United States Department of Energy (DOE); Pacific Northwest National Laboratory
  摘要：Marine stratocumulus clouds are the global reflectors, sharply contrasting with the underlying dark ocean surface and exerting a net cooling on Earth's climate. The magnitude of this cooling remains uncertain in part owing to the averaged representation of microphysical processes, such as the droplet-to-drizzle transition in global climate models (GCMs). Current GCMs parameterize cloud droplet size distributions as broad, cloud-averaged gammas. Using digital holographic measurements of discret...
• Can pollution-heavy steel manufacturing go green? AI翻译
  作者：Cornwall, Warren
  摘要：Department of Energy funds research to take carbon out of iron and steel production
• Antibody for childhood malaria AI翻译
  作者：Brainard, Jeffrey
• Philippine court blocks GM rice AI翻译
  作者：Brainard, Jeffrey
• All dog noses are created equal AI翻译
  作者：Brainard, Jeffrey
• Journals investigating Nobel winner's papers AI翻译
  作者：Else, Holly
  摘要：Thomas Sudhof's lab is facing scrutiny after admitting mistakes in 15 publications
• Pandemics and their accelerants AI翻译
  作者：Lynteris, Christos
  作者单位：University of St Andrews
  摘要：A well-researched account of the factors that drive pandemics misses an opportunity to indict broader social systems
• Ancient crystals suggest early Earth had land and freshwater AI翻译
  作者：Cutts, Elise
  摘要：Hardy zircon minerals found in Australian rocks hint that conditions for life existed 4 billion years ago
• Maternal mortality rate dives AI翻译
  作者：Brainard, Jeffrey