作者：Abdelwahab, Ibrahim; Kumar, Dushyant; Bian, Tieyuan; Zheng, Haining; Gao, Heng; Hu, Fanrui; McClelland, Arthur; Leng, Kai; Wilson, William L.; Yin, Jun; Yang, Hyunsoo; Loh, Kian Ping
作者单位：National University of Singapore; Harvard University; National University of Singapore; Netaji Subhas University of Technology; Hong Kong Polytechnic University; Shanghai University
摘要：Two-dimensional hybrid organic-inorganic perovskites with chiral spin texture are emergent spin-optoelectronic materials. Despite the wealth of chiro-optical studies on these materials, their charge-to-spin conversion efficiency is unknown. We demonstrate highly efficient electrically driven charge-to-spin conversion in enantiopure chiral perovskites (R/S-MB)(2)(MA)(3)Pb4I13 (< n > = 4), where MB is 2-methylbutylamine, MA is methylamine, Pb is lead, and I is iodine. Using scanning photovoltage...
作者：Moran, J. Conor; Brivanlou, Amir; Brischigliaro, Michele; Fontanesi, Flavia; Rouskin, Silvi; Barrientos, Antoni
作者单位：University of Miami; University of Miami; Harvard University; Harvard Medical School; University of Miami
摘要：The human mitochondrial genome encodes crucial oxidative phosphorylation system proteins, pivotal for aerobic energy transduction. They are translated from nine monocistronic and two bicistronic transcripts whose native structures remain unexplored, posing a gap in understanding mitochondrial gene expression. In this work, we devised the mitochondrial dimethyl sulfate mutational profiling with sequencing (mitoDMS-MaPseq) method and applied detection of RNA folding ensembles using expectation-m...
作者：Wilde, Jacob; Slack, Emma; Foster, Kevin R.
作者单位：University of Oxford; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Oxford; University of Oxford
摘要：Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their symbionts through diverse mechanisms, including immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable hosts to shape the ecology and evolution of microbiomes and generate natural selection for microbial tra...
作者：Verma, Anurag; Huffman, Jennifer E.; Rodriguez, Alex; Conery, Mitchell; Liu, Molei; Ho, Yuk-Lam; Kim, Youngdae; Heise, David A.; Guare, Lindsay; Panickan, Vidul Ayakulangara; Garcon, Helene; Linares, Franciel; Costa, Lauren; Goethert, Ian; Tipton, Ryan; Honerlaw, Jacqueline; Davies, Laura; Whitbourne, Stacey; Cohen, Jeremy; Posner, Daniel C.; Sangar, Rahul; Murray, Michael; Wang, Xuan; Dochtermann, Daniel R.; Devineni, Poornima; Shi, Yunling; Nandi, Tarak Nath; Assimes, Themistocles L.; Brunette, Charles A.; Carroll, Robert J.; Clifford, Royce; Duvall, Scott; Gelernter, Joel; Hung, Adriana; Iyengar, Sudha K.; Joseph, Jacob; Kember, Rachel; Kranzler, Henry; Kripke, Colleen M.; Levey, Daniel; Luoh, Shiuh-Wen; Merritt, Victoria C.; Overstreet, Cassie; Deak, Joseph D.; Grant, Struan F. A.; Polimanti, Renato; Roussos, Panos; Shakt, Gabrielle; Sun, Yan V.; Tsao, Noah; Venkatesh, Sanan; Voloudakis, Georgios; Justice, Amy; Begoli, Edmon; Ramoni, Rachel; Tourassi, Georgia; Pyarajan, Saiju; Tsao, Philip; O'Donnell, Christopher J.; Muralidhar, Sumitra; Moser, Jennifer; Casas, Juan P.; Bick, Alexander G.; Zhou, Wei; Cai, Tianxi; Voight, Benjamin F.; Cho, Kelly; Gaziano, J. Michael; Madduri, Ravi K.; Damrauer, Scott; Liao, Katherine P.
作者单位：University of Pennsylvania; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System; Harvard University; Harvard Medical School; United States Department of Energy (DOE); Argonne National Laboratory; University of Pennsylvania; Columbia University; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Harvard University; Harvard Medical School; United States Department of Energy (DOE); Oak Ridge National Laboratory; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Utah System of Higher Education; University of Utah; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Vanderbilt University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego; US Department of Veterans Affairs; Utah System of Higher Education; University of Utah; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Tennessee Valley Healthcare System; Vanderbilt University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Brown University; University of Pennsylvania; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Portland Health Care System; Oregon Health & Science University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai; University of Pennsylvania; Emory University; Rollins School Public Health; Yale University; Yale University; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Stanford University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Vanderbilt University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Pennsylvania; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran Program, a longitudinal study of diverse United States Veterans. Systematic analysis revealed 13,672 ...
作者：Ateia, Mohamed; Scheringer, Martin
作者单位：United States Environmental Protection Agency; Rice University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Masaryk University
摘要：Per- and polyfluoroalkyl substances (PFAS) are a large group of more than 10,000 synthetic chemicals widely used for providing heat, water, oil, and stain resistance in applications such as nonstick coatings, firefighting foam, and food packaging. These forever chemicals are hazardous for human health and the environment, motivating efforts to find suitable replacements ( 1 ). The concerns surrounding PFAS are particularly serious because of their unusual persistence and widespread use, result...
